RESUMEN
BACKGROUND: Cancer is becoming more common worldwide, affecting one third of the world’s population, and its morbidity and mortality are high. With the deep understanding of the cancer molecular biology, new cancer treatment programs continue to appear, and monoclonal antibody targeted drug therapy and immunotherapy have brought new hope to cancer patients. However, the lack of good models has hindered our understanding of tumor biology and the discovery of real drug targets. Effective in vitro tumor models are of great significance for the biological screening of anticancer drugs. OBJECTIVE: To summarize the application and prospect of induced pluripotent stem cells in tumor diseases. METHODS: PubMed, Web of Science and CNKI databases were searched for the articles concerning the induced pluripotent stem cells. The keywords were “induced pluripotent stem cells, tumor diseases, gene editing, regenerative medicine” in English and Chinese, respectively. After screening based on the inclusion and exclusion criteria, the articles with high relevance were included for review RESULTS AND CONCLUSION: Induced pluripotent stem cells have the advantages of wide sources, direct isolation from human peripheral blood, and being induced to differentiate into tumor tissues in vitro. Thus, more and more induced pluripotent stem cells for disease modeling and drug screening are being explored. With the continuous development of gene editing technology (CRISPER/Cas9), gene editing of stem cells has become possible to treat tumor diseases.