RESUMEN
Background: Diabetes is a condition which is known to be associated with a variety of connective tissue abnormalities which contribute to impaired wound healing, leading to the chronic ulcer formation. Centella asiatica Linn. and Garcinia mangostana Linn. are widely used as Thai traditional medicine including wound treatment. However, the effects of both plant extracts in diabetic condition had not been experimented.Objective: To study the effects of topical administration of Centella asiatica Linn. and Garcinia mangostana Linn. on diabetic wound.Materials and Methods: Male Spraque-Dawley rats (64 rats) were divided into 2 groups: Normal control and diabetes induced groups, each group was divided into 4 groups. The wounds were and treated by placebo, Centella asiatica Linn., Garcinia mangostana Linn. and neomycin.Results: It was shown that the wounds of the treated group epithelialized faster and the wound contraction rate was higher than the non-treated groups.Conclusion: The present study results confirmed the folkloric utilization and suggested the beneficial effects of both plant extracts for treating diabetic wounds in human being. However, the further studies with purified constituents were required to understand the complete mechanism of wound healing promotion induced by both Centella asiatica Linn. and Garcinia mangostana Linn.Key words: wound healing, diabetes, Centella asiatica Linn., Garcinia mangostana Linn.