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Yonsei Medical Journal ; : 1-9, 1973.
Artículo en Inglés | WPRIM | ID: wpr-12096

RESUMEN

Local anesthetics at a concentration of 10 mM(procaine and lidocaine) were found to inhibit competitively Ca++ binding to lipidextracted RBC membrane, and also to egg albumin film fixed on cover glasses or impregnated into Whatman filter paper (No. 1). A competitive inhibition by local anesthetics was also found in Ca++ binding to Whatman filter paper which had been pretreated with organic solvents to extract possible contaminated lipids. Therefore, it is suggested that the local anesthetics inhibit Ca++ binding not only to phospholipids but to some macromolecules such as membrane proteins, egg albumin film and filter paper.


Asunto(s)
Humanos , Anestésicos Locales/farmacología , Calcio/metabolismo , Permeabilidad de la Membrana Celular/efectos de los fármacos , Eritrocitos/citología , Filtración , Lidocaína/farmacología , Ovalbúmina/metabolismo , Procaína/farmacología
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