Collection Method and Specificity Analysis of Korean HLA Anti-Body Sera

In order to obtain a reliable test result of the HLA detection of major histocompatibility antigen, it is very significant to get complete result by using excellent anti-sera. so far no standard sera for HLA type has been seen in Korean people. Because we have been unable to find Korean specific antigen in Korea, we have performed screening test on the 150 pregenancy women in order to find an excellent Korean anti-HLA anti-body sera. To get panel lympocyte reaction, 20 healthy Korean and 34 healthy japanese who were well aware of HLA type were given microlymphocyte toxicity test of Thrasaki method. The result showed the the 10percent of the 150 persons had anti HLA sera. Of 10 percent, 2 persons indicated having P 50. it is estimated that there are unknown A, B locus blank and antigen still seisted among many Koreans and we are ging to screen about 2,000 more persons in the future.

Significance of HLA Type and Frequency of Korean HLA

Through the recent study, we have come to know that the gene group, which has an important function, is closely existed in the part of 6 chromosome short arm of a human being. Gene group consists of a major histocompatibility complex which develops rejective reaction in the process of kidey tranplantation, the gene group which controls immune response and the gene group which decides serum compliment component. These are called HLA in total. Through HLA-a.B.C. typhing, we may be able to find the following: 1. It is polymorphic, the gene group of A.B.C.D. DR locus is found along with many haplo-type. 2. Antigen differs accorbing to race. Example: HLA B8=White people 0.1% Oriental people 0.001% 3. It is related to disease. 4. There are few cases in the Department of Pediatrics but the result Shows A2, A9, B5 and B40 which is very similar to that of Japanese. There has been no Korean specific antigen founb yet.