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1.
Indian J Dermatol Venereol Leprol ; 2007 Mar-Apr; 73(2): 94-6
Artículo en Inglés | IMSEAR | ID: sea-52319

RESUMEN

BACKGROUND: Twenty percent azelaic acid gel is recommended as a topical treatment for acne due to its favorable profile. AIM: Our objective in this study was to evaluate the efficacy of 20% azelaic acid gel in the treatment of mild to moderate acne vulgaris. METHODS: This was a double blind, randomized clinical trial. Sixty patients with mild to moderate acne vulgaris were selected randomly to receive either azelaic acid gel or the vehicle gel alone. Patients were followed up every 15 days for a period of 45 days. The number of lesions and the acne severity index (ASI) were recorded and compared using Student's t-test. RESULTS: Total lesion count was reduced by 60.6% and 19.9% by azelaic acid gel and the placebo respectively (P = 0.002). ASI was reduced by 65.2% and 21.3% by azelaic acid gel and the placebo respectively (P = 0.001), i.e, azelaic acid gel was 3.06 times more effective than the placebo in reducing ASI. CONCLUSION: Azelaic acid gel can be used as an effective treatment in mild to moderate acne vulgaris.


Asunto(s)
Acné Vulgar/tratamiento farmacológico , Adolescente , Adulto , Fármacos Dermatológicos/administración & dosificación , Ácidos Dicarboxílicos/administración & dosificación , Método Doble Ciego , Femenino , Geles , Humanos , Masculino , Estudios Prospectivos , Resultado del Tratamiento
2.
Indian J Dermatol Venereol Leprol ; 2007 Jan-Feb; 73(1): 22-5
Artículo en Inglés | IMSEAR | ID: sea-53188

RESUMEN

BACKGROUND: Finding an effective treatment for acne that is well tolerated by the patients is a challenge. One study has suggested the efficacy of tea tree oil in treatment of the acne vulgaris. AIM: To determine the efficacy of tea tree oil in mild to moderate acne vulgaris. METHODS: This was a randomized double-blind clinical trial performed in 60 patients with mild to moderate acne vulgaris. They were randomly divided into two groups and were treated with tea tree oil gel (n=30) or placebo (n=30). They were followed every 15 days for a period of 45 days. Response to treatment was evaluated by the total acne lesions counting (TLC) and acne severity index (ASI). The data was analyzed statistically using t-test and by SPSS program. RESULTS: There were no significant differences regarding demographic characteristics between the two groups. There was a significant difference between tea tree oil gel and placebo in the improvement of the TLC and also regarding improvement of the ASI. In terms of TLC and ASI, tea tree oil gel was 3.55 times and 5.75 times more effective than placebo respectively. Side-effects with both groups were relatively similar and tolerable. CONCLUSION: Topical 5% tea tree oil is an effective treatment for mild to moderate acne vulgaris.


Asunto(s)
Acné Vulgar/tratamiento farmacológico , Administración Tópica , Adolescente , Adulto , Antiinfecciosos Locales/administración & dosificación , Método Doble Ciego , Femenino , Geles , Humanos , Masculino , Índice de Severidad de la Enfermedad , Aceite de Árbol de Té/administración & dosificación , Resultado del Tratamiento
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