The effect of the type of anesthesia on the quality of postoperative recovery after orthopedic forearm surgery / 대한마취과학회지

Background@#Although the quality of postoperative recovery may be affected by factors, there are few investigations whether the type of anesthesia also affects it. In this single-blinded, prospective, observational study, we compared the quality of postoperative recovery in patients undergoing orthopedic forearm surgery under general or regional anesthesia (brachial plexus block). @*Methods@# Ninety-seven subjects, aged 18–65 years and American Society of Anesthesiologists physical status I or II, undergoing orthopedic forearm surgery, were allocated to general or regional anesthesia group. The quality of postoperative recovery was assessed using a validated Korean version of Quality of Recovery-40 (QoR-40K) questionnaire. Patients were surveyed three times, the day before surgery (baseline) and 1st and 7th day after the surgery, and the scores of both groups were compared. @*Results@# We analyzed 47 and 50 patients in general and regional anesthesia, respectively. The global QoR-40K score and those of each of its five dimensions were not significantly different between the two groups at baseline, 1st and 7th day postoperatively. In two-way RM ANOVA, the global QoR-40K score at postoperative 1st day was significantly lower than that of baseline (P < 0.001) and postoperative 7th day (P < 0.001), respectively, in both general and regional anesthesia groups. However, there was no significant difference at each timepoint between the two groups. @*Conclusions@# The present study suggests that brachial plexus block with intravenous dexmedetomidine infusion does not improve the quality of postoperative recovery compared to sevoflurane inhalation anesthesia with remifentanil infusion in patients undergoing orthopedic forearm surgery.

Effects of preoperative oral carbohydrate administration on patient well-being and satisfaction in thyroid surgery / 대한마취과학회지

BACKGROUND: Although the positive effects of preoperative oral carbohydrate administration on clinical outcomes followingmajor surgery have been reported continuously, there are few investigations of them in minor surgical patients. Thepresent study was designed to examine the effects of preoperative oral carbohydrate administration on patient well-beingand satisfaction in patients undergoing thyroidectomy. METHODS: Fifty adults aged 20–65 years and scheduled for elective thyroidectomy in first schedule in the morning wereallocated to one of two groups. The Control group (n = 25) was requested to obey traditional preoperative fasting aftermidnight prior to the day of surgery. The Carbohydrate group (n = 25) also fasted overnight but drank 400 ml of carbohydrate-richdrink 2 hours before induction of anesthesia. Patient well-being (thirst, hunger, mouth dryness, nauseaand vomiting, fatigue, anxiety and sleep quality) and satisfaction were assessed just before the operating room admission(preoperative) and 6 hours following surgery (postoperative). Other secondary outcomes including oral Schirmer’s testand plasma glucose concentrations were also evaluated. RESULTS: The two groups were homogenous in patient characteristics. Seven parameters representing patient well-beingevaluated on NRS (0–10) and patient satisfaction scored on a 5-point scale were not statistically different between thetwo groups preoperatively and postoperatively. There were no statistically significant differences in secondary outcomes. CONCLUSIONS: Preoperative oral carbohydrate administration does not appear to improve patient well-being and satisfactioncompared with midnight fasting in patients undergoing thyroidectomy in first schedule in the morning.

The comparison of two different intraarticular injections using a sonographic anterolateral approach in patients with osteoarthritic knee

BACKGROUND: The intraarticular (IA) injection has become popular for the management of the osteoarthritic knee without an effusion. The success rate of IA injection would be better if it was able to be visually confirmed. We hypothesized that an anterolateral approach, which targets the synovial membrane of the lateral condyle using ultrasound, would provide an equivalent alternative to the anterolateral approach, targeting the synovial membrane of the medial condyle for IA injection of the knee. METHODS: A total of 96 knees with osteoarthritis were randomized placed into the two groups, which were group I (anterolateral approach to the medial condyle) and group II (anterolateral approach to the lateral condyle). The primary outcome was to compare the success rate of the two methods of IA injection. The required length of the needle for injection was also measured and compared. Pain intensity was assessed using the Numeric Rating Scale in order to evaluate the success of injection. RESULTS: There were no significant differences in the success rate between both groups. The success rate of group I and group II were 87.8% (95%, CI 78.7–97.0) and 91.5% (95%, CI 83.6–99.5), respectively (P = 0.549). The needle depth was 5.0 ± 0.8 (3.0 to 6.1 cm) in group I, and 3.0 ± 0.8 (1.5 to 5 cm) in group II (P < 0.001). CONCLUSIONS: The anterolateral approach to the lateral femoral condyle, using ultrasound, is an alternative method to the approach targeting the medial femoral condyle, using shorter needle.

Comparing the Rates of Dopamine Hemodynamic Effect Onset after Infusion through Peripheral Veins in Three Regions / 대한중환자의학회지

BACKGROUND: Dopamine is an inotropic agent that is often selected for continuous infusion. For hemodynamic stability, the rate of infusion is controlled in the range of 5-15 µg/kg/min. This study aimed to compare the time intervals from the administration of dopamine to the onset of its hemodynamic effects when dopamine was administered through three different peripheral veins (the cephalic vein [CV], the great saphenous vein [GSV], and the external jugular vein [EJV]). METHODS: Patients in group 1, group 2, and group 3 received dopamine infusions in the CV, GSV, and EJV, respectively. A noninvasive continuous cardiac output monitor (NICCOMO™, Medis, Ilmenau, Germany) was used to assess cardiac output (CO) and systemic vascular resistance (SVR). Six minutes after intubation, baseline heart rate (HR), systolic blood pressure (BP), diastolic BP, mean arterial pressure (MAP), CO, and SVR values were recorded and dopamine infusion was initiated at a dose of 10 µg/kg/min. Hemodynamic changes at 0, 4, 8, 12, and 15 minutes postinfusion were recorded. RESULTS: No statistically significant differences were observed among the three groups with respect to the rate of hemodynamic change. In all groups, systolic BP, diastolic BP, MAP, and SVR tended to increase after decreasing for the first 4 minutes; in contrast, HR and CO decreased until 8 minutes, after which they tended to reach a plateau. CONCLUSIONS: For patients under general anesthesia receiving dopamine at 10 µg/kg/min, there were no clinical differences in the effect of dopamine administered through three different peripheral veins.

Comparing the Rates of Dopamine Hemodynamic Effect Onset after Infusion through Peripheral Veins in Three Regions / 대한구급학회지

BACKGROUND: Dopamine is an inotropic agent that is often selected for continuous infusion. For hemodynamic stability, the rate of infusion is controlled in the range of 5-15 µg/kg/min. This study aimed to compare the time intervals from the administration of dopamine to the onset of its hemodynamic effects when dopamine was administered through three different peripheral veins (the cephalic vein [CV], the great saphenous vein [GSV], and the external jugular vein [EJV]). METHODS: Patients in group 1, group 2, and group 3 received dopamine infusions in the CV, GSV, and EJV, respectively. A noninvasive continuous cardiac output monitor (NICCOMO™, Medis, Ilmenau, Germany) was used to assess cardiac output (CO) and systemic vascular resistance (SVR). Six minutes after intubation, baseline heart rate (HR), systolic blood pressure (BP), diastolic BP, mean arterial pressure (MAP), CO, and SVR values were recorded and dopamine infusion was initiated at a dose of 10 µg/kg/min. Hemodynamic changes at 0, 4, 8, 12, and 15 minutes postinfusion were recorded. RESULTS: No statistically significant differences were observed among the three groups with respect to the rate of hemodynamic change. In all groups, systolic BP, diastolic BP, MAP, and SVR tended to increase after decreasing for the first 4 minutes; in contrast, HR and CO decreased until 8 minutes, after which they tended to reach a plateau. CONCLUSIONS: For patients under general anesthesia receiving dopamine at 10 µg/kg/min, there were no clinical differences in the effect of dopamine administered through three different peripheral veins.

The changes of endotracheal tube cuff pressure by the position changes from supine to prone and the flexion and extension of head / 대한마취과학회지

BACKGROUND: The proper cuff pressure is important to prevent complications related to the endotracheal tube (ETT). We evaluated the change in ETT cuff pressure by changing the position from supine to prone without head movement. METHODS: Fifty-five patients were enrolled and scheduled for lumbar spine surgery. Neutral angle, which was the angle on the mandibular angle between the neck midline and mandibular inferior border, was measured. The initial neutral pressure of the ETT cuff was measured, and the cuff pressure was subsequently adjusted to 26 cmH2O. Flexed or extended angles and cuff pressure were measured in both supine and prone positions, when the patient's head was flexed or extended. Initial neutral pressure in prone was compared with adjusted neutral pressure (26 cmH2O) in supine. Flexed and extended pressure were compared with adjusted neutral pressure in supine or prone, respectively. RESULTS: There were no differences between supine and prone position for neutral, flexed, and extended angles. The initial neutral pressure increased after changing position from supine to prone (26.0 vs. 31.5 +/- 5.9 cmH2O, P < 0.001). Flexed and extended pressure in supine were increased to 38.7 +/- 6.7 (P < 0.001) and 26.7 +/- 4.7 cmH2O (not statistically significant) than the adjusted neutral pressure. Flexed and extended pressure in prone were increased to 40.5 +/- 8.8 (P < 0.001) and 29.9 +/- 8.7 cmH2O (P = 0.002) than the adjusted neutral pressure. CONCLUSIONS: The position change from supine to prone without head movement can cause a change in ETT cuff pressure.

A comparison of desflurane consumption according to fresh gas flow / 대한마취과학회지

No abstract available.

The comparison of the lengths and diameters of main bronchi measured from two-dimensional and three-dimensional images in the same patients / 대한마취과학회지

BACKGROUND: Recently, multi-planar reconstruction of the three-dimensional (3D) spiral chest CT scan has demonstrated superiority in the evaluation of the tracheobronchial tree. The goal of this study was to measure the lengths of the right and left main bronchi and their anteroposterior (AP) and transverse (TR) diameters using the 3D and two-dimensional (2D) images in the same adult respectively, and to evaluate the degree of correlation between them. METHODS: We measured the lengths of the right and left main bronchi from the carina to the first of their branches and the AP and TR diameters at the mid-portion of the right main bronchus and 2 cm below the carina in the left main bronchus. We determined the size of the left-sided double-lumen tube (DLT) based on the measured AP diameter of the left main bronchus from the 3D and 2D images, respectively. RESULTS: There was moderate correlation between the lengths of both main bronchi obtained from the 3D images and the 2D images, and between the AP diameter of the left main bronchus obtained from the 3D images and the 2D images. Same sized DLTs were estimated in 69% of the men and 34% of the women. CONCLUSIONS: The lengths of the right and left main bronchi and their AP and TR diameters obtained from 3D images were not strongly correlated with those from 2D images. Therefore, a further study is needed to verify the superiority of 3D images in selecting the appropriate size of left-sided DLT.

Effect of ketorolac on the prevention of emergence agitation in children after sevoflurane anesthesia / 대한마취과학회지

BACKGROUND: The purpose of this study was to evaluate the effects of ketorolac on the incidence and severity of emergence agitation in children recovering from sevoflurane anesthesia. METHODS: Eighty-five children aged 3 to 7 years were randomly assigned to the control group or the ketorolac group (1 mg/kg ketorolac). The children were evaluated by the Pediatric Anesthesia Emergence Delirium Scale and a four-point agitation scale. RESULTS: The median agitation scores did not differ significantly between the two groups. The overall incidence of emergence agitation was similar in the two groups (41% in the control group vs. 32% in the ketorolac group, P = 0.526). The number of children who received rescue drugs for treatment of emergence agitation was not significantly different between the two groups. CONCLUSIONS: The administration of 1 mg/kg of ketorolac is not effective in decreasing the incidence and severity of emergence agitation in children aged 3 to 7 years after sevoflurane anesthesia.

What is the Optimal Effect-site Concentration of Remifentanil for Minimizing the Cardiovascular Changes to Endotracheal Intubation during Induction with Propofol? / 대한마취과학회지

BACKGROUND: In this study, the optimal effect-site concentration of remifentanil for blunting hemodynamic responses to endotracheal intubation during total intravenous anesthesia using propofol were evaluated. METHODS: 137 ASA class I and II patients, aged 18-60 years, were randomly allocated to one of six groups according to the effect-site concentration of remifentanil. Remifentanil was then infused at a target effect-site concentration of 0, 1, 2, 3, 4 or 6 ng/ml in groups R0, R1, R2, R3, R4 and R6, respectively. Anesthesia was induced with propofol infusion at a target effect-site concentration of 4microgram/ml endotracheal intubation was performed 5 minutes after remifentanil administration. Blood pressure (BP), heart rate (HR) and cardiac index (CI) were recorded at the baseline and then every 30 seconds until 3 minutes after intubation. RESULTS: BP and HR in groups R0, R1 and R2 increased significantly after intubation when compared with the baseline values. The CI in group R0 also increased significantly after intubation when compared with the baseline values. Incidences of hypertension and hypotension were 50% and 5% in R0, 32% and 14% in R1, 18% and 32% in R2, 10% and 48% in R3, 8% and 54% in R4, and 0% and 81% in R6. There were also 2 cases in which the mean blood pressure was less than 50 mmHg in group R6. CONCLUSIONS: We suggest that the optimal target effect-site concentrations of remifentanil for blunting hemodynamic responses to endotracheal intubation are 3 or 4 ng/ml during total intravenous anesthesia using propofol at an effect-site concentration of 4microgram/ml.

The Effective Pressure Value of an Inflatable Wedge in Preventing Postoperative Backache following Surgical Operation in the Lithotomy Position

BACKGROUND: Backache is a common complication following anesthesia and surgery. Previous studies indicated that the use of a lumbosacral wedge was effective in reducing the incidence of postoperative backache. We investigated the effective inflation pressure of an inflatable wedge in preventing postoperative backache following spinal anesthesia and surgery in the lithotomy position. METHODS: A pilot study established a mean comfortable pressure for the wedge when used to support the lumbar curvature. In males and females, the mean pressure values were 23.6 +/- 3.1 mmHg and 18.9 +/- 3.7 mmHg, respectively. The design of the main study was a randomized, controlled trial involving the use of a wedge intra-operatively in patients undergoing spinal anesthesia and urological surgery in the lithotomy position. Fifty male and 50 female patients were included in the main study and randomly allocated to the control or study group. In the study group, the wedge was inserted immediately after the induction of anesthesia and maintained during surgery. On the first day after surgery, all patients were asked whether they had backache. If there was backache, the degree of pain was noted using the numeric rating scale (NRS). RESULTS: In the study and control groups of male patients, the incidence of backache was 16% and 24%, respectively. There was no significant difference between the two groups. In the study and control groups of female patients, the incidence of backache was 20% and 52%, respectively (P < 0.05). Where backache occurred, there was no significant difference in its severity between the study and control groups. CONCLUSIONS: The effective pressure value of an inflatable wedge in preventing postoperative backache following spinal anesthesia and surgical operation in lithotomy position was 19 mmHg in female patients.

Changes in Hemostatic Function Evaluated by Thromboelastography during the Normal Menstrual Cycle / 대한마취과학회지

BACKGROUND: As the menstruation has been thought to be associated with abnormal hemostasis and increased fibrinolytic activities, some surgeons and even anesthesiologists tend to postpone elective surgery. Many investigators have studied individual coagulation profiles and fibrinolytic activity during the menstruation, but conventional coagulation screens are frequently inadequate for the purpose of monitoring coagulation dynamically. This study was designed to evaluate the whole dynamic hemostatic process globally during the normal menstrual cycle by the thromboelastography (TEG). METHODS: Thirty six-healthy, normally menstruating female volunteers wrote a menstruation diary about their menstruation cycle. Blood samples were obtained for TEG analysis 3 days before menstruation, the 1st day of menstruation, the 2nd day of menstruation, the last day of menstruation and 5 days after menstruation. TEG coagulation indices (R value, K value, alpha angle, MA value and WBCLI60) were measured and statistically analysed with repeat-measured one way ANOVA. RESULTS: There were no significant difference in R value, K value, alpha angle, WBCLI60 during menstruation compared with pre- or post-menstruation period, but there was a significant decrease in the MA value on the 1st day of the menstruation. CONCLUSIONS: The result of our study showed the possibility of abnormal hemostatic function on the 1st day of menstruation. However, the more study is needed to confirm the possibility of bleeding tendency during surgery on the 1st day of menstruation.

Traumatic Aortic Regurgitation Caused by Blunt Chest Injury / 대한마취과학회지

Blunt chest trauma can result in significant cardiothoracic injury, which can include a cardiac contusion, aortic injury, and myocardial valvular injury. Traumatic aortic regurgitation is an uncommon consequence of closed chest injury. Isolated aortic valvular injury following blunt chest trauma is difficult to diagnose in a patient with multiple injuries. We report a case of traumatic aortic regurgitation which was detected just before anesthesia induction in the operating room. This report is presented to emphasize the possibility of aortic regurgitation and the need for careful evaluation of the cardiac status in patients with blunt chest trauma.

Comparison between the Flexiblade Laryngoscope and the Macintosh Blade Laryngoscope in Endotracheal Intubation / 대한마취과학회지

BACKGROUND: The Flexiblade laryngoscope has a unique structure that is composed of a blade and a handle with a trigger. When the trigger of the Flexiblade laryngoscope is squeezed, the hyoepiglottic ligament is depressed, the epiglottis is moved anteriorly, and then the laryngoscopic grade is improved. This study was designed to compare the Flexiblade laryngoscope with the conventional Macintosh blade laryngoscope in the laryngoscopic view in endotracheal intubation. METHODS: Following induction of general anesthesia, the laryngoscopic grades of 110 patients were evaluated while five different blade positions of the Flexiblade laryngoscope and a laryngoscopy with the Macintosh blade were performed. The laryngoscopic grades which were described by Cormack and Lehane were classified from 1 to 4. RESULTS: With the Macintosh blade laryngoscope, 98.2% of the patients were grade one and two, and 98.2% of the patients was laryngoscopic grade one and two with partial depression of the trigger of the Flexiblade laryngoscope. The laryngoscopic grade of maximal depression of the Flexiblade trigger had similar results to partial depression of the trigger. However, the partial depression of the Flexiblade laryngoscope showed better laryngoscopic views than the maximal depression of the Flexiblade laryngoscope or the Macintosh blade laryngoscope, respectively. In the overall success rate of endotracheal intubation and using the adjusting maneuvers, the Flexiblade laryngoscope was superior to the Macintosh blade laryngoscope. CONCLUSIONS: The Flexiblade laryngoscope is comparable to the Macintosh blade laryngoscope for endotracheal intubation, therefore, the Flexiblade laryngoscope can be recommended as the first choice for endotracheal intubation.

The Effect of Age on the Cardiovascular Responses Induced by High Concentration of Isoflurane / 대한마취과학회지

BACKGROUND: The inhalation of a high concentration of isoflurane transiently increases heart rate (HR) and blood pressure. The current study examined the effects of age on isoflurane-induced circulatory responses. METHODS: One hundred-ten patients were randomly allocated into one of four groups according to age: under 10 years (Group 1), 20 - 40 years (Group 2), 41 - 60 years (Group 3), and over 65 years (Group 4). In each group, the inspired concentration of isoflurane via mask was increased to 5.0 vol% abruptly. The target was to produce an end-tidal concentration of isoflurane (ETisof) of 2.6 vol% which was maintained until the end of the study by adjusting the vaporizer setting when necessary. HR, mean arterial pressure (MAP), ETisof, and end-tidal concentration of carbon dioxide were measured at baseline and every 30 seconds for 5 minutes after inhalation of isoflurane and for 2 minutes after intubation. RESULTS: HR and MAP significantly increased after inhalation of isoflurane in all four groups compared with the baseline. The time from administration of isoflurane to the maximal HR was less than that for MAP. However, there were no significant differences among the groups for ETisof at the maximal HR and MAP. In Groups 1 and 4, the times for maximal HR were shorter than in Groups 2 and 3. In aged patients (Group 4), the isoflurane-induced HR increase was less than in the other three groups. There were no significant differences among the groups in increases of MAP. CONCLUSIONS: The high concentration of isoflurane transiently increases HR and MAP during inhaled anesthesia induction. In aged patients, the increase in HR is less than in younger-aged patients.

A Comparison of the Blind Intubation and the Fiberscope-guided Intubation Techniques via Laryngeal Mask Airway / 대한마취과학회지

BACKGROUND: The laryngeal mask airway (LMA) has an established role in difficult airway management as a ventilatory device and airway intubator. It is ease to view the laryngeal aperature with a fiberscope through a laryngeal mask airway, so it offers a route to obtaining rapid access to the larynx. The objective of this study was to evaluate a narrowing degree of LMA by the epiglottis and to compare the intubation time and success rate of the blind intubation techinique with the fiberscope-guided intubation techinique through the laryngeal mask airway. METHODS: The LMA (#4) was placed into the hypopharynx after induction of anesthesia and muscle paralysis. The fiberscopic findings through the lumen of the LMA were recorded after the LMA placements. The degree of narrowing of the LMA by the epiglottis was estimated as 0%, 1 25%, 26 50%, 51 75%, or 76 100%. The breathing circuit of the anesthesia circle system was then disconnected from the LMA and a well-lubricated, cuffed, 5.5 mm ID endotracheal tube was inserted into the trachea through the lumen of the LMA either by the blind techiniques or fiberscope-guided techniques, and then intubation time and success rate were measured. RESULTS: The most frequent incidence (44/60, 73.3%) of narrowing by epiglottis in both groups was 76 100%. The success rate for fiberscope-guided intubation was 100%, while the success rate for blind intubation was 20%. The average intubation time of fiberscope-guided intubation was 26.0 s, while the average intubation time of blind intubation was 17.7 s. CONCLUSIONS: The fiberscope-guided tracheal intubation technique through the LMA is a more reliable method than the blind intubation technique through the LMA.

A Comparison of the Blind Intubation and the Fiberscope-guided Intubation Techniques via Laryngeal Mask Airway / 대한마취과학회지

BACKGROUND: The laryngeal mask airway (LMA) has an established role in difficult airway management as a ventilatory device and airway intubator. It is ease to view the laryngeal aperature with a fiberscope through a laryngeal mask airway, so it offers a route to obtaining rapid access to the larynx. The objective of this study was to evaluate a narrowing degree of LMA by the epiglottis and to compare the intubation time and success rate of the blind intubation techinique with the fiberscope-guided intubation techinique through the laryngeal mask airway. METHODS: The LMA (#4) was placed into the hypopharynx after induction of anesthesia and muscle paralysis. The fiberscopic findings through the lumen of the LMA were recorded after the LMA placements. The degree of narrowing of the LMA by the epiglottis was estimated as 0%, 1 25%, 26 50%, 51 75%, or 76 100%. The breathing circuit of the anesthesia circle system was then disconnected from the LMA and a well-lubricated, cuffed, 5.5 mm ID endotracheal tube was inserted into the trachea through the lumen of the LMA either by the blind techiniques or fiberscope-guided techniques, and then intubation time and success rate were measured. RESULTS: The most frequent incidence (44/60, 73.3%) of narrowing by epiglottis in both groups was 76 100%. The success rate for fiberscope-guided intubation was 100%, while the success rate for blind intubation was 20%. The average intubation time of fiberscope-guided intubation was 26.0 s, while the average intubation time of blind intubation was 17.7 s. CONCLUSIONS: The fiberscope-guided tracheal intubation technique through the LMA is a more reliable method than the blind intubation technique through the LMA.

A Case of Cardiac Arrest due to Drug Interaction between Halothane and Aminophylline: A case report / 대한마취과학회지

Although halothane is generally anesthetic of choice for asthmatics due to its bronchodilatory action, its combined use with aminophylline should be discouraged. This report is a 43-year-old male who had primary closure and open reduction internal fixation (ORIF) for facial avulsion injury and zygomatic tripod fracture under N2O-O2-halothane anesthesia. About 90 minutes after the procedure, the patient who had aminophylline infusion for an acute bronchospasm developed a sudden cardiac arrest. The immediate cardiopulmonary resuscitation was applied and the patient was recovered without any neurological deficit. At the time, the serum theophylline concentration of the patient was 16 microgram/ml which was in the range of normal therapeutic dose. The cause for this cardiac arrest by halothane is unknown, but possibly a drug interaction between halothane and aminophylline might have contributed, since halothane sensitizes the heart to exogenous catecholamines.

Effects of Induced Hypotension with Labetalol on Blood Loss and Blood Pressure in Maxillofacial Surgical Patients / 대한마취과학회지

BACKGROUND: The worst problem in anesthetic management of maxillofacial surgery is bleeding from bone cutting site. Induced hypotension reduces bleeding and minimizes the need for blood transfusion. This study was performed to evaluate the effects of induced hypotension with labetalol on blood loss and blood pressure in maxillofacial surgical patients. METHODS: Twenty-four adult patients, either sex, ASA physical status I or II, undergoing orthognathic surgery were randomly selected and divided into two groups; one group was administered 20 mg of labetalol and the other group was not. Anesthetic maintenance was consisted of O2-N2O-enflurane (2~2.5 vol%). Then 20 mg of labetalol was given intravenously at skin incision time in the labetalol group. Hemodynamic variables were recorded before induction of anesthesia, at the beginning of the labetalol infusion and at 10 min, 20 min, 30 min, 60 min and 90 min after the infusion. Blood loss determined by measuring the weight of the sponges and by measuring the volume of blood in suction-trap bottle. RESULTS: There was no significant difference in preoperative hemoglobin and postoperative hemoglobin between two groups. The amount of blood loss in the labetalol group (408 +/- 202 ml) was less than those in the control group (450 +/- 255 ml), but statistically not significant. The blood pressure was significantly decreased in the labetalol group than those of the control group at 20 minutes after the labetalol infusion. CONCLUSIONS: Labetalol is a useful agent for inducing hypotension. But 20 mg of labetalol was insufficient to decrease the blood loss. So I think the more amount of labetalol required to reduce the blood loss.

The Comparison of the Anesthetic Regimens for Functional Direct Cortical Stimulation Mapping during Craniotomy / 대한마취과학회지

BACKGROUND: Recently, functional direct cortical stimulation mapping is frequently used during craniotomy for the surgery of brain pathology (tumors, epileptic foci etc.) within or close to the central motor area. We reviewed and analyzed our experiences to evaluate the safety and efficacy of our hospital's anesthetic management regimens. METHODS: We used three anesthetic regimens (isoflurane fentanyl; propofol fentanyl; awake craniotomy, conscious sedation analgesia) in 44 patients. We evaluated the success ratio of mapping and the incidence of intraoperative problems (seizures, changes in vital signs etc) in each regimens. RESULTS: In awake craniotomy group, functional mapping is performed successfully in all patients but there were some intraoperative problems (hypertension; 3 in 11 patients, hypercapnia; 3 in 11 patients, change to general anesthesia required; 1 in 12 patients). In general anesthesia groups, there were no significant differences between isoflurane treated patients and propofol treated patients in the success ratio of mapping (17/20 vs 11/12) and the incidence of intraoperative problems (seizure; 3/20 vs 1/12, hypertension; 2/20 vs 1/12). CONCLUSION: This results suggest that the anesthetic management regimens used in our hospital provide suitable conditions for craniotomies when brain mapping is required.