Correlation between serum thyroid hormone and dopamine levels and Chinese medicine syndrome types / 中国中西医结合杂志

<p><b>OBJECTIVE</b>To analyze the correlation between changes of thyroid hormone (TH), dopamine (DA) and Chinese medicine syndrome types by detecting contents of serum TH and DA in insomnia, thus to explore objective indices of Chinese medicine syndrome types.</p><p><b>METHODS</b>Insomnia patients were assigned to four Chinese medicine syndrome types groups, covering depressed Gan transforming into fire, internal disturbance by phlegm-heat, excessive fire due to yin deficiency, and Xin-Pi deficiency. One healthy control group was set up. Each group consisted of 30 patients or subjects. Serum DA content was determined using spectrophotofluorometry. Serum levels of 3,5,3'-triiodothyronine (T3) and tetraiodothyronine (T4) were detected using radioimmunoassay (RIA).</p><p><b>RESULTS</b>The serum levels of DA and TH showed difference among groups at various levels. The serum DA level was sequenced from high to low as the control group > the depressed Gan transforming into fire group > the excessive fire due to yin deficiency group > the internal disturbance by phlegm-heat group > the Xin-Pi deficiency group. The serum TH level was sequenced from high to low as the excessive fire due to yin deficiency group > the depressed Gan transforming into fire group > the internal disturbance by phlegm-heat group > the control group > the Xin-Pi deficiency group.</p><p><b>CONCLUSIONS</b>Serum DA levels in insomnia patients were in line with the disease course and the dynamic change from sthenia to asthenia in Chinese syndrome types. Serum DA levels, as one of pathological factors constituting the sthenia syndrome or the asthenia syndrome, may be taken as an objective indicator in Chinese medicine syndrome typing.</p>

Effect of kangxin capsule on homocysteine and beta-amyloid protein in vascular dementia patients / 中国中西医结合杂志

<p><b>OBJECTIVE</b>To observe the effect of Kangxin capsule (KXC) on homocysteine (HCY) and beta-amyloid protein (beta-Ap) in patients with vascular dementia.</p><p><b>METHODS</b>Sixty-three patients with vascular dementia were randomly divided into two groups, the 33 patients in the treated group and the 30 in the control group. Basal treatment were given to both groups, besides, KXC was given to the treated group and Hydergine was given to the control group. The levels of plasma HCY, beta-Ap as well as the changes of mini mental state examination (MMSE), activity of daily living (ADL) and TCM Syndrome scoring were observed before and after treatment.</p><p><b>RESULTS</b>KXC could significantly decrease the levels of HCY and beta-Ap (P < 0.01), rise the MMSE scores, reduce ADL scores and ameliorate TCM Syndrome.</p><p><b>CONCLUSION</b>KXC can effectively regulate the levels of HCY, beta-Ap in vascular dementia patients.</p>

Clinical study on effect of yuantong capsule in treating vascular dementia / 中国中西医结合杂志

<p><b>OBJECTIVE</b>To observe the clinical effect of Yuantong Capsule (YTC) in treating vascular dementia (VD).</p><p><b>METHODS</b>Eighty-three patients of VD were randomized on ratio of 2:1 into two groups, the 54 patients in the treated group were treated with YTC orally administered, 3 times a day, 1 capsule in each time. The remaining 29 patients in the control group were treated with Hydergine orally, 3 times a day, 2 mg in each time. The therapeutic course for both groups was 2 months.</p><p><b>RESULTS</b>The therapeutic effect in the treated group was significantly better than that in the control group, significant difference (P < 0.05 or P < 0.01) was shown in comparison of the two groups in terms of the mini-mental state examination (MMSE) and activity of daily living (ADL) test, symptoms scoring, total effective rate, and laboratory indexes findings.</p><p><b>CONCLUSION</b>The therapeutic effect of YTC in treating VD was obvious.</p>

Determining blood parameters FT3, FT4, T, E2 and cortisol to explore nature of cold syndrome and heat syndrome / 中国中西医结合杂志

<p><b>OBJECTIVE</b>To explore the relationship between the levels of free triiodothyronine (FT3), free thyroxine (FT4), cortisol (CO), testosterone (T), serum estradiol (E2) and Cold Syndrome and Heat Syndrome in traditional Chinese medicine.</p><p><b>METHODS</b>The blood levels of FT3, FT4, T, E2, CO in groups of sthenic Heat (SH), sthenic Cold (SC), asthenic Heat (AH) and asthenic Cold (AC) and the healthy control group were measured. The number of cases in each group was 50.</p><p><b>RESULTS</b>(1) FT3 and FT4 were higher in Heat Syndrome than that in Cold Syndrome in the order of AH > SH > control > SC > AC, it revealed that the basal metabolic rate and oxygen consumption in Heat Syndrome were increased, while it in Cold Syndrome, it declined. (2) CO was higher in SH, SC than that in AH and AC, the order was SC > SH > control > AH > AC, it revealed that CO was one of the factors correlated to asthenic and sthenic syndrome, but not relevant to Heat Syndrome and Cold Syndrome. (3) T was higher in Heat Syndrome than that in Cold Syndrome, but E2 showed the opposite, suggesting that T was one of the factors for forming Heat Syndrome, and E2 for Cold Syndrome.</p><p><b>CONCLUSION</b>The levels of FT3, FT4, T, E2 are basis of pathophysiology related with forming HS and CS.</p>