RESUMEN
Coenzyme Q[10], a lipid soluble benzoquinone, has excellent antioxidant and membrane stabilizing properties in the cardiac tissue. The present study investigated the effects of coenzyme Q[10] on in vitro LDL oxidation quantitavely. The formation of conjugated dienes, malondialdehyde [MDA] and electrophoretic mobility were monitored as markers of the oxidation of LDL, respectively. Coenzyme Q[10] showed a decrease the formation of conjugated dienes and MDA, respectively, against oxidation in vitro. Coenzyme Q[10] also reduced electrophoretic mobility of the oxidized human LDL. Thus, results showed that the coenzyme Q10 exhibits strong antioxidant activity in CuSO[4]-mediated oxidation of LDL [P<0.05] in vitro. The inhibitory effects of the coenzyme Q[10] on LDL oxidation were dose-dependent at concentrations ranging from 20 nM to 300 nM. Moreover, the effects of coenzyme Q[10] on LDL oxidation were compared with vitamin E and vitamin C. This study showed that coenzyme Q[10] is a potent antioxidant to protect LDL against oxidation in vitro and may be a good alternative to reduce the risk of atherosclerosis and coronary heart disease and other free radical associated health problems