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Chinese Journal of Biotechnology ; (12): 324-329, 2010.
Artículo en Chino | WPRIM | ID: wpr-336224

RESUMEN

Cytoplasmic transduction peptide (CTP) is a newly designed transduction peptide, by which special molecules can be carried out and localized into cytoplasmic compartment. Superoxide dismutase (SOD) is a protein that is difficult to go into cytoplasm. In this study, CTP-SOD fusion gene was amplified from human cDNA by PCR, and the active recombinant protein was successfully expressed in Pichia pastoris. HeLa cells pretreated with CTP-SOD showed a significantly improved survival against the pyrogallol-induced oxidative stress, suggesting CTP-SOD could cross the cell membrane more efficiently and protect cells from oxidative stress.


Asunto(s)
Humanos , Antioxidantes , Farmacología , Citoplasma , Metabolismo , Vectores Genéticos , Genética , Células HeLa , Péptidos y Proteínas de Señalización Intracelular , Genética , Metabolismo , Estrés Oxidativo , Pichia , Genética , Metabolismo , Proteínas Recombinantes de Fusión , Genética , Farmacología , Transducción de Señal , Fisiología , Superóxido Dismutasa , Genética , Metabolismo
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