Effet antiproliferatif de plants medicinales sur une lignee cancereuse du col de l'uterus

In order to seak natural molecules with antiviral properties, we have evaluated the effect of 15 extracts of Moroccan plants used in traditional medicine on the proliferation of a cell line cancer cervix carrier of papillovirus type 16 [SiHa]. Evaluation of the resultes obtained which are due to inhibition of cellular growth was expressed in terms of variation of 50% inhibitory concentration [IC50] depending on the concentration of the product in correlation with its time of contact with the cells. Among the 15 tested extracts only the oily extracted Origanum compactum showed a significant decrease of the IC50 compared to the results of cidofovir used as a positive control. These results suggested the presence of one or more products responsible for the antiproliferative activity in the oily extract of Origanum compactum

HPV typing and cervical cancer screening: results of Moroccan critical study

Cancer of the uterine cervix, the second most frequent cancer after breast cancer in Morocco, is closely linked to several types of Human Papilloma Virus [HPV] especially the potentially oncogenic types 16 and 18 mostly found in high grade precancerous lesions and uterine cervix cancer. In the Bethesda cytological classification, HPV infection and Cervical Intraepithelial Neoplasia grade I [CIN 1] are classified as Low grade Squamous Intraepithelial Lesions [LSIL] whereas CIN 2 and CIN 3 are considered High grade Squamous Intraepithelial Lesions [HSIL]. The cytologic diagnosis of HPV infection on cervical Pap smears relies on the association of several criteria of which koilocytosis is considered specific of HPV infection. Colposcopy and direct biopsies are therefore necessary to cofirm the diagnosis. Nevertheless, since the introduction of HPV typing in uterine cervix cancer screening, koilocytosis is disregarded as a necessary criteria for the diagnosis of HPV infection. The authors report the results of a study which corroborate this statement and correlate histopathology and HPV typing of benign lesions collected at our institution [INO]. Guidelines for follow-up are also discussed according to the data in the literature