RESUMEN
Twenty four rats divided into four equal groups were used. Group I was kept as a control. Group II was exposed to halothane 2% for 20 minutes every other day for 13 exposure. The animals of Group III and IV were subjected for 20 minutes of stress by hitting on their cages in non-rhythmic fashion. Group III was exposed to oxygen. While Group IV was exposed to 2% halothane in oxygen for 13 exposures similar to Group II. Liver sections were stained with H and E., PAS and sundan blackstains. Degenerative changs in the hepatocytes appeared following exposure to halothane, while necrosis of the hepatocytes was seen following stress in Group III and became marked with exposure to halothane after the period of stress in Group IV. Glycogen content decreased particularly with halothane. Lipid content decreased with halothan exposure in Group II but relatively increased with stress in Group III and the hepatocytes became loaded with fat granules with halothane and stress in group IV