RESUMEN
The current work comprises the formulation and evaluation of verapamil with respect to developing and preparing a verapamil releasing system for transdermal application. Eudragit RL-100 and Eudragit RS-100 were used to prepare pseudolatices and matrix diffusion patches. The effect of surfactant, such as Tween 80 and Oleth 10, on the release rate of verapamil was evaluated. These preparations were evaluated for in vitro release and permeation of the drug across hairless mouse skin. The drug plasma profiles were compared with the plasma profile obtained following the administration of oral dose of verapamil. The most promising in vivo availability of the drug was recorded with Oleth 10 pseudolatex. The AUC0-infinity for the selected formula is larger than AUC0-infinity for oral route. Skin irritation studies indicated that neither verapamil nor the pseudolatex caused any appreciable skin irritation