RESUMEN
The mental health of LGBTQ+ individuals is often marred by societal stigma and discrimination. However, recent strides in LGBTQ+ rights, particularly the legalization of same-sex marriage, present promising prospects.This article examines the intersection of LGBTQ+ mental health and same-sex marriage, emphasizing the positive effects on well-being.Legal recognition of same-sex marriage is associated with improved mental health outcomes, including reduced rates of depression and anxiety, heightened social support, and enhanced self-esteem. Moreover, it fosters societal acceptance, diminishes internalized stigma, and promotes positive parenting experiences within LGBTQ+ families.Additionally ,same-sex marriage yields economic advantages, such as financial stability and increased workplace productivity among LGBTQ+ individuals. Despite these advancements, disparities persist, with many countries yet to legalize same-se x marriage and LGBTQ+ individuals facing ongoing discrimination.Continuous advocacy efforts are vital to ensure equal rights and protections for the LGBTQ+ community globall.
RESUMEN
Arbutin is utilized in traditional remedies to cure numerous syndromes because of its anti-microbial, antioxidant, and anti-inflammatory properties. This study aimed to evaluate chemopreventive effects of arbutin on azoxymethane (AOM)-induced colon aberrant crypt foci (ACF) in rats. Five groups of rats were used: normal control group (rats injected hypodermically with sterile phosphate-buffered saline once per week for two weeks) and groups 2-5, which were subcutaneously inoculated with 15 mg/kg AOM once a week for two weeks. AOM control and 5-fluorouracil (5-FU) control groups were fed 10% Tween orally daily for 8 weeks using a feeding tube. The treated groups were fed 30 and 60 mg/kg arbutin every day for 2 months. ACF from the AOM control group had aberrant nuclei in addition to multilayered cells and an absence of goblet cells. The negative control group displayed spherical cells and nuclei in basal positions. Histological examination revealed a reduced number of AFC cells from colon tissues of the 5-FU reference group. Arbutin-fed animals showed down-regulation of proliferating cell nuclear antigen (PCNA) and up-regulation of Bax protein compared to AOM control. Rats fed with arbutin displayed a significant increase of superoxide dismutase (SOD) and catalase (CAT) activities in colon tissue homogenates compared to the AOM control group. In conclusion, arbutin showed therapeutic effects against colorectal cancer, explained by its ability to significantly decrease ACF, down-regulate PCNA protein, and up-regulate Bax protein. In addition, arbutin significantly increased SOD and CAT, and decreased malondialdehyde (MDA) levels, which might be due to its anti-proliferative and antioxidant properties.
RESUMEN
Thyroid nodules represent a prevalent condition that is detectable via palpation or ultrasound. In recent years, there has been a paradigm shift toward enhanced diagnostic precision and less aggressive therapeutic approaches, highlighting the growing necessity for tailored clinical recommendations to optimize patient outcomes. The Korean Thyroid Association (KTA) has developed guidelines for managing patients with thyroid nodules, following a comprehensive review by task force members of the relevant literature identified via electronic database searches. The recommendations are provided with a level of recommendation for each section. The guidelines encompass thyroid cancer screening in high-risk groups, appropriate diagnostic methods for thyroid nodules, role of pathologic and molecular marker testing in making a diagnosis, long-term follow-up and treatment of benign thyroid nodules, and special considerations for pregnant women. The major revisions that were made in the 2023 guidelines were the definition of high-risk groups for thyroid cancer screening, application of the revised Korean Thyroid Imaging Reporting and Data System (K-TIRADS), addition of the role of core needle biopsy and molecular marker tests, application of active surveillance in patients with low-risk papillary thyroid microcarcinoma, and updated indications for nonsurgical treatment of benign thyroid nodules. In the 2024 revision of the KTA guidelines for thyroid cancer, the evidence for some recommendations has been updated to address the tumor size in the context of active surveillance in patients with low-risk thyroid cancer and the surgical size cutoff. These evidence-based recommendations serve to inform clinical decision-making in the management of thyroid nodules, thereby facilitating the delivery of optimal and efficacious treatments to patients.
RESUMEN
Differentiated thyroid cancer demonstrates a wide range of clinical presentations, from very indolent cases to those with an aggressive prognosis. Therefore, diagnosing and treating each cancer appropriately based on its risk status is important. The Korean Thyroid Association (KTA) has provided and amended the clinical guidelines for thyroid cancer management since 2007. The main changes in this revised 2024 guideline include 1) individualization of surgical extent according to pathological tests and clinical findings, 2) application of active surveillance in low-risk papillary thyroid microcarcinoma, 3) indications for minimally invasive surgery, 4) adoption of World Health Organization pathological diagnostic criteria and definition of terminology in Korean, 5) update on literature evidence of recurrence risk for initial risk stratification, 6) addition of the role of molecular testing, 7) addition of definition of initial risk stratification and targeting thyroid stimulating hormone (TSH) concentrations according to ongoing risk stratification (ORS), 8) addition of treatment of perioperative hypoparathyroidism, 9) update on systemic chemotherapy, and 10) addition of treatment for pediatric patients with thyroid cancer.
RESUMEN
ABSTRACT Introduction: The evidence for using del Nido cardioplegia protocol in high-risk patients with reduced ejection fraction undergoing isolated coronary surgery is insufficient. Methods: The institutional database was searched for isolated coronary bypass procedures. Patients with ejection fraction < 40% were selected. Propensity matching (age, sex, infarction, number of grafts) was used to pair del Nido (Group 1) and cold blood (Group 2) cardioplegia patients. Investigation of biomarker release, changes in ejection fraction, mortality, stroke, perioperative myocardial infarction, composite endpoint (major adverse cardiac and cerebrovascular events), and other perioperative parameters was performed. Results: Matching allowed the selection of 45 patient pairs. No differences were noted at baseline. After cross-clamp release, spontaneous sinus rhythm return was observed more frequently in Group 1 (80% vs. 48.9%; P=0.003). Troponin values were similar in both groups 12 and 36 hours after surgery, as well as creatine kinase at 12 hours. A trend favored Group 1 in creatine kinase release at 36 hours (median 4.9; interquartile range 3.8-9.6 ng/mL vs. 7.3; 4.5-17.5 ng/mL; P=0.085). Perioperative mortality, rates of myocardial infarction, stroke, or major adverse cardiac and cerebrovascular events were similar. No difference in postoperative ejection fraction was noted (median 35.0%; interquartile range 32.0-38.0% vs. 35.0%; 32.0-40.0%; P=0.381). There was a trend for lower atrial fibrillation rate in Group 1 (6.7% vs. 17.8%; P=0.051). Conclusion: The findings indicate that del Nido cardioplegia provides satisfactory protection in patients with reduced ejection fraction undergoing coronary bypass surgery. Further prospective trials are required.
RESUMEN
SUMMARY OBJECTIVE: Inflammation plays a key role in the pathogenesis of postoperative atrial fibrillation after coronary artery bypass graft surgery. In this study, we aimed to investigate the changes in mean platelet volume and platelet values during the spring and autumn seasons in patients who underwent isolated coronary artery bypass graft surgery and the possible effect of these occurrences on postoperative atrial fibrillation. METHODS: Consecutive patients who underwent elective isolated coronary bypass surgery at our clinic in the spring and autumn months, between August 2020 and July 2022, were retrospectively included in this study. Variables were evaluated according to the spring and autumn seasons. Patients who did not develop in-hospital postoperative atrial fibrillation were identified as Group 1, and those who did constituted Group 2. RESULTS: A total of 622 patients were included in the study. The patients were divided into two groups: those who were operated on in the spring (n=277, median age=62 years, male gender ratio=77.3%) and those who were operated on in the autumn (n=345, median age=61 years, male gender ratio=81.4%). There was no statistically significant difference between the patients operated on in both seasons in terms of age, gender, hypertension rates, and the frequency of chronic obstructive pulmonary disease. In multivariate analysis, being over 70 years old (OR: 1.934, 95% confidence interval (CI) 1.489-2.995, p<0.001), having a left ventricular ejection fraction below 30% (OR: 1.550, 95%CI 1.190-2.236, p=0.012), and having chronic obstructive pulmonary disease (OR: 1.663, 95%CI 1.339-2.191, p<0.001) were found to be independent predictors in predicting the development of postoperative atrial fibrillation. CONCLUSION: In this study, we first demonstrated that mean platelet volume and platelet mass index values were higher in patients in the autumn months. Additionally, for the first time in the literature, we showed that there is a significant relationship between platelet mass index value and the development of postoperative atrial fibrillation in patients who underwent isolated coronary artery bypass graft.
RESUMEN
ABSTRACT Postoperative pain after cardiac surgery plays an important role in the patient's recovery process. In particular, pain at the chest tube site can negatively affect the comfort and recovery of these patients. Effective pain control minimizes the risk of many complications. Oral and intravenous analgesics, epidural anesthesia, paravertebral block, and intercostal nerve blockade are used in chest tube pain control. We routinely use the surgical cryoablation method in the presence of atrial fibrillation in the preoperative period of cardiac surgery in our clinic. Here we aimed to describe our method of using the cryoablation catheter for intercostal nerve blockade.
RESUMEN
SUMMARY OBJECTIVE: The aim of this study was to investigate whether there is a difference in serum nitric oxide levels between patients who return spontaneously after cardiopulmonary resuscitation and those who do not. We also examined the potential of using serum nitric oxide levels as a marker to make an accurate decision about patient survival. METHODS: We included 100 consecutive patients who were brought to the emergency clinic due to cardiac arrest. Blood samples were taken from these patients at admission, 30 min after admission, and when resuscitation was terminated. RESULTS: We found that there was a significant difference in NO1 and NO3 values between the group of patients who did not return after cardiopulmonary resuscitation and the group in which spontaneous circulation returned. The NO1 value was significant in the receiver operating characteristic (ROC) analysis, while the NO3 value was not. A higher NO1 value provided a higher rate of survival. CONCLUSION: Our findings suggest that nitric oxide may be a useful parameter to support the decision about patient survival. A higher NO1 value is associated with a better prognosis and survival rate. Therefore, serum nitric oxide levels may be a suitable indicator to support the decision-making process regarding patient survival.
RESUMEN
Aim: Foliar nutrition is aimed to eliminate the problems of fixation and immobilization of nutrients. Hence, foliar application of plant growth hormones is being recognized as a significant way of fertilizing modern agriculture, especially under rainfed conditions. Growth regulating substances or growth regulators are known to influence a wide array of physiological parameters like alteration of plant architecture, assimilate partitioning, promotion of photosynthesis, uptake of nutrients (mineral ions) and enhancing metabolism.Study Design: The experiment was laid out in Randomized complete block design with three replications.Place and Duration of Study: A field experiment was conducted in medium black to deep black soil with clay loam texture at Agricultural Research Station, Bheemarayanagudi, Yadgir district during kharif season of 2022.Methodology: The experiment consisted of eleven treatments viz., T1: Control (water spray), T2: Pulse magic @ 10 g l-1 at flower initiation, T3: Nitrobenzene @ 500 ppm at flower initiation, T4: Urea @ 2 % spray at flower initiation, T5: DAP @ 2 % spray at flower initiation, T6: N: P: K (19:19:19) @ 2 % spray at flower initiation, T7: Boron @ 0.25 % spray at flower initiation, T8: Urea @ 2 % + salicylic acid @ 75 ppm spray at flower initiation, T9: DAP @ 2 % + salicylic acid @ 75 ppm spray at flower initiation, T10: N: P: K (19:19:19) @ 2 % + salicylic acid @ 75 ppm spray at flower initiation and T11: Boron @ 0.25 % + salicylic acid @ 75 ppm spray at flower initiation. Results: Foliar application of DAP @ 2 % + salicylic acid @ 75 ppm at flower initiation was found beneficial for growth and yield of greengram along with higher net returns and benefit-cost ratio (BC ratio). Alternately, foliar application of N:P:K (19:19:19) @ 2 % + salicylic acid @ 75 ppm at flower initiation stage or foliar application of pulse magic @ 10 g l-1 at flower initiation stage can be recommended for achieving higher net returns from greengram cultivation.Conclusion: Foliar application of nutrients and plant growth hormones would reduce the burden on soil application of fertilizers through urea and DAP for greengram cultivation. Thereby, cost incurred on fertilizers could be reduced and net returns could be increased. Foliar application of DAP @ 2 % + salicylic acid @ 75 ppm at flower initiation was found beneficial for growth and yield of greengram.
RESUMEN
The field investigation was carried out to evaluate the influence of fertigation levels, mulch and drip irrigation levels on yield and yield quality at WTC fields, PJTSAU, Rajendranagar, Telangana during 2020-21 and 2021-22. The study was consisted of 12 treatment combinations viz. 75%, 100% (300-60-120 kg ha-1 N-P2O5-K2O & 125% RDF, drip irrigation levels (0.8 Epan & 1.0 Epan) imposed under factorial combination of mulch (M1) and no mulch (M0) conditions. An investigation was undertaken during rabi season. Among the fertigation levels, 100% RDF (31.15 t ha-1, 195.04 mg 100 g-1, 10.33% & 0.94%, respectively) recorded the higher fresh fruit yield, ascorbic acid content, oleoresin content and capsaicin content in pooled data. With regards to mulch, the M1 has recorded the maximum values for fresh fruit yield (37.56 t ha-1), ascorbic acid content (224.43), oleoresin content (11.11%) and capsaicin content (0.74%) in pooled data.
RESUMEN
The present investigation entitled “Effect of different concentrations of auxin hormone (IBA) upon promoting root development of stem cuttings in the ‘Scented Geranium’, Pelargonium graveolens L” was carried out at Medicinal and Aromatic Plants Research Station, (MAPRS) Rajendranagar, Sri Konda Laxman Telangana State Horticultural University, Hyderabad during December 2022 to February 2023. The experiments were conducted using a Completely Randomized Design (CRD) with three replications under a shade net house. Each replication consisted of seven treatments, which included a control group and six different concentrations of IBA (500 mg L-1, 1000 mg L-1, 1500 mg L-1, 2000 mg L-1, 2500 mg L-1, 3000 mg L-1). The results indicated, that among the various IBA concentrations tested, specifically IBA @ 2000 mg L-1 for stem cuttings, proved to be more effective than all other treatments in terms of various root parameters. It recorded the minimum days taken for root initiation and also recorded better results for the number of roots per cutting, average length of roots per cutting, length of longest root per cutting, fresh weight of roots per cutting, and dry weight of roots per cuttings.
RESUMEN
The present study of experiment entitled on the strategies for management of pink boll worm Pectinophora gossypiella (Saunders) in cotton though different methods was conducted in famers fields as a form of Frontline Demonstration (FLD). The experiment was conducted in 30 locations in Nalgonda and Yadadri bhuvangiri distrits of Telangana during kharif 2018, 2019 and 2020 respectively. The results revealed that, due to the adoption of IPM practices in addition to good agricultural practices, the average kapas yield was high in IPM demonstration plots (1857.0 kg/ha) with 12.0% increase over the farmers’ practice (1658 kg/ha) during three years of study.The average gross returns of Rs.1,01,007/ha, net returns of Rs.52,027/ha, and Benefit-cost ratio of 2.05 was recorded as higher in the demonstration plot as compared to farmers practice Rs. 90,121/ha, Rs.37,430 and 1.69 respectively during the study period. The additional average net returns of Rs.14,597/ha and reduction in the cost of cultivation of Rs.1912/ha were saved per year.
RESUMEN
A field experiment was conducted to study the effect of mulching and tillage practices on yield & yield attributs of sorghum at Regional Agricultural Research Station, Andhra Pradesh during 2020-21 & 2021-22 Kharif seasons. Mulching, Tillage practices and their interaction showed no significant influence on growth parameters viz., plant height and dry matter production at harvest, days to 50 % population. Whereas, panicle weight, panicle length, grain yield, straw yield and harvest index were significantly higher with zero tillage and with residue mulch. The interaction between tillage and mulch practices was non significant. Maximum gross and net returns were observed with zero tillage with residue mulch practice in grain sorghum. The economic evaluation of mulching and tillage practices in sorghum crop revealed that maximum gross returns (Rs 1,18,659), net returns (Rs 78,579) and B:C ratio (2.96) were obtained with zero tillage practice with mulching practice. The study indicated that tillage and mulching had significant effect on soil fertility and grain yield of sorghum crop.
RESUMEN
Background: Depression is characterized by persistent sadness and lack of interest or pleasure in enjoyable activities and disturbed sleep and appetite. Women suffer from depression the most, as the hurdles faced by Indian women include lack of awareness, stigma, disadvantaged position of women, multiple roles, increased levels of stress, and domestic violence.This study is to determine the prevalence of depression among elderly women and to determine the factors affecting it. Methodology: This cross-sectional study was conducted among 783 elderly women (aged 60 years or more), residing in rural Mandya (South Karnataka) by interviewing them using a semi-structured proforma. Geriatric Depression Scale (GDS-15) was used to assess depression. Mean, standarddeviation and proportion were used for descriptive statistics. Chi square test was used to de-termine association of risk factors. Results: The prevalence of depression was found to be 31.6%. The major factors affecting depression were increasing age, illness and loneliness. Conclusions: The prevalence of depression in the elderly women was high (31.6%). By identifying risk fac-tors for depression among the elderly population and screening them on time, we can reduce the severity and burden of the disease to a greater extent.
RESUMEN
Patent foramen ovale(PFO) is a relatively uncommon anatomical variant that predisposes patients to several complications, such as atrial septal aneurysm, thromboembolism, stroke, platypnea-orthodeoxia, and paradoxical embolism. Despite this, in rare cases, PFO can be a life-saving factor. We present a 72-year-old man with a PFO and fulfilled Virchov’s triad after being stationary, dehydrated, and suffering from chronic venous insufficiency. A subsequent transesophageal echocardiogram revealed a large thrombus (approx. 20 cm in length) dwelling in the PFO in between both atria. In this case, PFO effectively saved the patient from such complications as pulmonary embolism and paradoxical embolism
RESUMEN
Background: This experiment has been designed for you to learn more about the way the cardiovascular system how it respond toward exercise. The prevalence of cardiovascular disease and its resultant debilitation of cardiac performance are expected to increase in the future generation. Eelier research on cardiovascular adaptations to endurance training has primarily focused on young generation. Recent work on the present study indicates that the basis of trained older male’s increased aerobic power is their superior ability to increase stroke volume during exercise, which, in turn, allows them to marked increase in cardiac output. Aims and Objectives: The aim of the study was to assess the differences in cardiovascular responses to exercise in trained and untrained individuals. Materials and Methods: In this, 100 subjects were included and divided into trained (50) and untrained (50) for a minimum of 1 year duration by the time of study and 50 untrained individuals acted as controls. Institution ethics committee permission obtained and the subjects performed four exercise sessions per week for a minimum of 1 year duration by the time of study; supervised by the personal trainers at gym center, according to instructions. Results: The mean resting heart rate (HR) of strength trained was lesser when compared to mean resting HR of untrained. Conclusion: Regular strength training exercise results in a decrease in weight, body fat, resistance of insulin, triglycerides, and an increase in excess good cholesterol levels. Regular strength training exercise if performed within normal limits decreases cardiovascular risk factors.
RESUMEN
Background: Acne vulgaris is a common dermatological disease affecting 85% of adolescents across the globe with 40% having persistent acne well into their twenties. Acne and post-inflammatory hyperpigmentation often negatively impact self-perception, social interactions, and affect quality of life scores in adolescents. Aims and Objectives: The aim of the study was to evaluate the prescription pattern of drugs used in the treatment of acne to find out the current prescribing practices relating to comprehensive care being provided at a tertiary care hospital. Materials and Methods: This was a cross-sectional and observational study conducted after getting approval of Institutional Ethics Committee on 135 patients of either sex and age more than 12 and ?40 years diagnosed with acne. Results: Data of 135 prescriptions of acne patients were analyzed. Most patients presented with Grade 2 (n = 56; 41.5%) acne followed by Grade 3 acne (n = 40; 29.6%) patients. The average numbers of drugs per prescription was 3.87. Out of 522 drugs prescribed, 436 (83.5%) were topical and 86 (16.5%) were oral formulations. Among topical formulations, most frequently prescribed drug was tretinoin prescribed to 92 (68.1%) patients whereas, doxycycline was the most preferred oral antibiotic prescribed to 66 (48.9%) patients. Conclusion: The study revealed that drugs prescribed were found to be in accordance with the treatment guidelines proposed by Indian dermatologists and American Academy of Dermatology.
RESUMEN
Pregnancy in patients with Eisenmenger syndrome (ES) is associated with high maternal mortality rates of 30%‒50%, or even up to 65% in the case of a cesarean section (Yuan, 2016). Here, we report a case of term pregnancy complicated with ES and severe pulmonary artery hypertension (PAH), which was managed by a multidisciplinary team (MDT) and resulted in an uncomplicated delivery via elective cesarean section. The goal of this study is to emphasize the importance of multidisciplinary approach in the management of pregnancy with ES, which can profoundly improve maternal and infant outcomes.
Asunto(s)
Femenino , Humanos , Embarazo , Cesárea , Complejo de Eisenmenger/terapia , Hipertensión Pulmonar/terapia , Mortalidad Materna , Complicaciones Cardiovasculares del Embarazo/terapia , Resultado del EmbarazoRESUMEN
Purpose@#We developed a comprehensive return to work (RTW) intervention covering physical, psycho-social and practical issues for patients newly diagnosed and evaluated its efficacy in terms of RTW. @*Materials and Methods@#A multi-center randomized controlled trial was done to evaluate the efficacy of the intervention conducted at two university-based cancer centers in Korea. The intervention program comprised educational material at diagnosis, a face-to-face educational session at completion of active treatment, and three individualized telephone counseling sessions. The control group received other education at enrollment. @*Results@#At 1-month post-intervention (T2), the intervention group was more likely to be working compared to the control group after controlling working status at diagnosis (65.4% vs. 55.9%, p=0.037). Among patients who did not work at baseline, the intervention group was 1.99-times more likely to be working at T2. The mean of knowledge score was higher in the intervention group compared to the control group (7.4 vs. 6.8, p=0.029). At the 1-year follow-up, the intervention group was 65% (95% confidence interval, 0.78 to 3.48) more likely to have higher odds for having work. @*Conclusion@#The intervention improved work-related knowledge and was effective in facilitating cancer patients’ RTW.