RESUMEN
<p><b>OBJECTIVE</b>To study processing method and mechanism of Calamine.</p><p><b>METHOD</b>Thermogravimetry analysis method and nano-technology were adopted to analyze and synthesize the components in Calamine, Tetracycline was took as the comparison drug to determine the antibacterial activity of Calamine and its components.</p><p><b>RESULT</b>A part of zinc carbonate in Calamine was decomposed into zinc oxide when processing, and the particle size was smaller than before. The antibacterial activity of Calamine is decided by the content and particle size of zinc oxide, and has nothing with zinc carbonate. The more content and the smaller particle size of zinc oxide, the more powerful antibacterial activity of Calamine.</p><p><b>CONCLUSION</b>The content and the particle size of zinc oxide can be the important targets in the processing of Calamine.</p>