RESUMEN
Objectives: To study the lipid levels in patients with lichen planus and controls, to find the association of lichen planus with dyslipidemia and to find the association of lichen planus with metabolic syndrome
Methods This was a case-control study involving a total of 100 patients, consecutively visiting the Outpatient Dermatology Department at Karnataka Institute of Medical Sciences Hubli, Karnataka. Men and women with age more than 18 years [50 cases with Lichen planus and 50 controls without lichen planus and had other skin diseases mainly nevi, seborrheic keratosis, verruca vulgaris]
Results We found significantly higher levels of triglycerides [153.03 vs 107.91 p value 0.008], total cholesterol [158.49 vs 143.47 p value 0.018], VLDL [30.61 vs 22.75 p value 0.021] and significantly lower levels of HDL [38.86 vs 45.78 p value 0.00l]. Both TG/HDL ratio [4.26 vs 3.19] and LDL/HDL ratio [2.45 vs 1.78] were significantly higher with a p value of 0.0001. ATP-III criteria for metabolic syndrome were met by 6% of the patients with LP versus 2% of the controls [p value=0.617], suggesting no association between metabolic syndrome and lichen planus. The prevalence of dyslipidemia in patients with LP was 38% for cases and 6% for controls [p value< 0.001]
Amultivariate logistic regression model demonstrated that LP was associated with dyslipidemia, even after controlling for confounders, including age, gender, BMI and FBS levels [OR=11.53 95%, CI-2.80-47.55, p value 0.00l]
Conclusion The results obtained in our study support the association of dyslipidemia in lichen planus which was seen even after controlling the confounding factors
The study also highlights the importance of routine screening of dyslipidemia since early intervention may reduce the risk and complications of cardiovascular disease later in life. However, there was no association seen between lichen planus and metabolic syndrome. Further studies are required to establish this finding
RESUMEN
Objectives The study aimed [1] to compare incidence of co-morbidities among psoriatic patients [cases] and nonpsoriatic patients [controls], [2] to determine the association between psoriasis and various co-morbidities and [3] to determine the relationship between the severity of psoriasis and co-morbidities
Methods We performed a hospital-based case-control study involving 100 psoriatic patients [cases] and 100 age- and sex-matched nonpsoriatic patients [controls] from the dermatology outpatient department in a government teaching institute
Detailed history and examination was followed by relevant investigations. The severity of psoriasis was assessed according to Psoriasis Area and Severity Index [PASI], and body surface area [BSA] measurement. Cardiovascular risk factors were assessed by using the definition for metabolic syndrome, which includes the presence of three or more of the National Cholesterol Education Program's Adult Panel III [ATP III] criteria
Results The study revealed statistically significant association of psoriasis with metabolic syndrome [27% vs 8%, p = 0.0004] and psoriatic arthritis. Psoriatic patients had significantly higher levels of triglycerides [24% vs 8%, p = 0.002] and fasting blood sugar [23 % vs 8%, p = 0.003] along with significantly lower HDL levels [29 % vs 7%, p = 0.000, in males and 7% vs 2%, p = 0.043 in females]. Abdominal obesity was more prevalent in psoriatic patients [24 % vs 9%, p = 0.02 in male and 9 % vs 3%, p = 0.033 in females]. Neither metabolic syndrome nor psoriatic arthritis correlated with the severity of psoriasis
Conclusion There was higher prevalence of metabolic syndrome in patients with psoriasis. However, its presence did not correlate with either severity or duration of the psoriasis. Hence, we suggest that all patients need to be evaluated for metabolic syndrome irrespective of severity of psoriasis which is the risk factor for systemic diseases