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Indian J Lepr ; 2001 Apr-Jun; 73(2): 121-9
Artículo en Inglés | IMSEAR | ID: sea-55517

RESUMEN

This study analyses retrospectively some of the risks associated with the use of WHO-multidrug therapy (MDT) in Sri Lanka. Case records of 3,333 new cases of leprosy attending the Central Leprosy Clinic in Colombo during 1991-1995, were analysed for adverse drug reactions involving the liver and blood. There were 81 reports of suspected hepatic or haematological adverse reactions associated with the use of MDT, of which 39 were classified as haemolytic anaemia, 25 as toxic hepatitis, 2 as methaemoglobinaemia and 15 as anaemia. Dapsone, was incriminated in the majority of adverse reactions (72%). Adverse drug reactions were more common in female than male subjects (55% vs 45%; P < 0.5), but there was no significant differences between the age groups. Majority of adverse reactions was seen within the first three months of initiation of MDT. This study in no way undermines the benefits of MDT but highlights the risks and suggests measures to minimize these risks.


Asunto(s)
Adolescente , Adulto , Anemia/inducido químicamente , Niño , Clofazimina/efectos adversos , Dapsona/efectos adversos , Quimioterapia Combinada , Femenino , Enfermedad Hepática Inducida por Sustancias y Drogas/epidemiología , Humanos , Leprostáticos/efectos adversos , Lepra/tratamiento farmacológico , Masculino , Metahemoglobinemia/inducido químicamente , Persona de Mediana Edad , Estudios Retrospectivos , Rifampin/efectos adversos
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