RESUMEN
Oxydemeton-methyl, an organophosphate insecticide and acaricide produced decrease in the exploratory behaviour and prolongation of barbitone sodium induced hypnosis in rats after intermittent aerosol spray inhalational exposure, for 1/2 hour daily for 7 consecutive days, compared to the saline control group. Further, ED50 +/- SEM value for haloperidol induced catalepsy, CD50 +/- SEM value for pentylenetetrazole induced seizure and CI50 +/- SEM value for electroshock (i.e. the dose of haloperidol, PTZ and intensity of electroshock producing catalepsy or positive seizure response in 50% of rats) were significantly decreased after 7 days exposure to oxydemeton-methyl compared to that of saline control group. The study has established the central nervous system depressant effect, extrapyramidal effect and proconvulsant potential of oxydemeton-methyl which is widely used by the agricultural workers in the form of field spray.
Asunto(s)
Animales , Antipsicóticos/toxicidad , Barbital/farmacología , Conducta Animal/efectos de los fármacos , Catalepsia/inducido químicamente , Convulsivantes , Electrochoque , Conducta Exploratoria/efectos de los fármacos , Femenino , Haloperidol/toxicidad , Hipnóticos y Sedantes/farmacología , Insecticidas/toxicidad , Masculino , Sistema Nervioso/efectos de los fármacos , Compuestos Organotiofosforados/toxicidad , Pentilenotetrazol , Ratas , Ratas Sprague-Dawley , Convulsiones/inducido químicamente , Sueño/efectos de los fármacos , Factores de TiempoRESUMEN
Oxydemeton-methyl, an organophosphate insecticide and acaricide produced decrease in the exploratory behaviour and prolongation of barbitone sodium-induced hypnosis after intermittent aerosol spray inhalational exposure for 1 h in rats compared to the saline control group. Further, CD50 +/- S.E.M. value for pentylenetetrazole (PTZ) and CI50 +/- S.E.M. value for electroshock (i.e. the dose of PTZ and intensity of electroshock producing positive seizure response in 50% of rats) were significantly decreased by acute exposure to oxydemeton-methyl compared to that of saline control group. The study has established the central nervous system depressant effect and proconvulsant potential of oxydemeton-methyl which is widely used by the agricultural workers in the form of field spray.