Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Añadir filtros








Intervalo de año
1.
Braz. j. microbiol ; 44(4): 1315-1320, Oct.-Dec. 2013. ilus, tab
Artículo en Inglés | LILACS | ID: lil-705294

RESUMEN

In this study we report the potential of alcohols as morphogenetic regulators in Candida albicans. All the alcohols tested influenced various modes of growth like planktonic as well as biofilm forms. Viability was affected at high concentrations. Among the alcohols, the response of C. albicans to amyl alcohol (pentanol) was noteworthy. Amyl alcohol at a concentration 0.5% which was not inhibitory to growth and viability specifically inhibited morphogenetic switching from yeast to hyphal forms. It also inhibited normal biofilm development favoring yeast dominated biofilms. Based on this study we hypothesize that alcohols produced under anaerobic conditions may not favor biofilm development and support dissemination of yeast cells. Since anaerobic conditions are not found to favor production of quorum sensing molecules like farnesol, the alcohols may play a role in morphogenetic regulation.


Asunto(s)
Alcoholes/metabolismo , Biopelículas/crecimiento & desarrollo , Candida albicans/efectos de los fármacos , Candida albicans/fisiología , Candida albicans/citología , Candida albicans/crecimiento & desarrollo , Viabilidad Microbiana/efectos de los fármacos
2.
Braz. j. microbiol ; 44(3): 855-859, July-Sept. 2013. ilus, tab
Artículo en Inglés | LILACS | ID: lil-699817

RESUMEN

Candida infections are very common in cancer patients and it is a common practice to prescribe antifungal antibiotics along with anticancer drugs. Yeast to hyphal form switching is considered to be important in invasive candidiasis. Targeting morphogenetic switching may be useful against invasive candidiasis. In this study, we report the antimorphogenetic properties of thirty cancer drugs.


Asunto(s)
Humanos , Antifúngicos/farmacología , Antineoplásicos/farmacología , Candida albicans/efectos de los fármacos , Hifa/efectos de los fármacos , Candida albicans/citología , Candida albicans/crecimiento & desarrollo , Reposicionamiento de Medicamentos , Hifa/citología , Hifa/crecimiento & desarrollo , Pruebas de Sensibilidad Microbiana , Microscopía
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA