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Objective To investigate serum indicators of liver fibrosis in patients with chronic hepatitis in liver fibrosis diagnostic significance.Methods determination of serum HA,LN,PCⅢ,ⅣC was condueted by RIA technology in 100 cases of chonic hepatitis and 40 cases of healthy people,the difference of the findings was in two groups coup ared.Results There was signifieunt difference in terms of serum HA,LN,PCⅢ,ⅣC among normal control,moderafe hepatitis,sever hepatitis and cirrhosis group(P0.05).There was significant difference in ferms of serum HA,LN,PCⅢ,ⅣC among cirrhosis and mild,moderate,serere hepatitis as well as healthy control group(P
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Objective To investigate the distribution of hepatitis B virus(HBV)genotypes in Zhejiang.Methods HBV genotyps were detected by fluorimetric real-time PCR in 240 HBVDNA positive patients who were born in Zhejiang(Hangzhou,Huzhou,Jinhua,Shaoxing,Taizhou,Ningbo each 40 positive patients).Results of the 240 HNBDNA positive patients,82(34.17%)were genotype B,and 140(58.33%)were genotype C,15(6.25%)were genotype B and C,3(1.25%)were genotype D.No genotype A、E and F found in the studied subjects.Conclusions HBV genotype B,genotype C,genotype B and C,genotype D existed in Zhejiang and there is no difference in ferms of the distribution of genotypes in six areas metioned above.