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Objective: To show the preventive effect of Brazilian propolis on metabolic syndrome.Methods: Nine Brazilian propolis were examined for inhibition ofα-glucosidase, absorption of sugar in mice, and lipid accumulation, glycerol 3-phosphate dehydrogenase, and adiponection production in mouse 3T3-L1 cells.Results: In nine Brazilian propolis, AF-06, AF-19, and AFG-06 propolis inhibited rat internal α-glucosidase, and AF-06 propolis inhibited the absorption of sugar in mice. In 3T3-L1 cells, AF-06 and AF-08 propolis inhibited accumulation lipid, and inhibited glycerol 3-phosphate dehydrogenase.Conclusion: Brazilian propolis AF-06 and AF-08 are natural products which offer promise in the prevention of diabetes and metabolic syndrome. Incorporating dietary supplements into a treatment plan with medicines with similar effects requires further study.
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Cancer prevention is one of the most urgent problems in the field of public health worldwide. The methanol extract of watercress ( Nasturtium officinale) inhibits 12-O-tetradecaonoylphorbol-13-acetate (TPA)-induced ear edema in mice. The extract also exhibits marked antitumor activity in in vivo two-stage carcinogenesis test in mice using 7,12-dimethylbenz[α]anthracene as an initiator and TPA as a promoter. From the active fraction of the methanol extract, sitosterol 3-O-glucopyranoside (1) was isolated and identified. This compound was evaluated for its inhibitory effects on TPA-induced inflammation (1 µg/ear) in mice, and had a 50% inhibitory dose of 299 nmol/ear. These results indicate that watercress extracts are useful in cancer prevention.
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Cancer prevention is an important issue in the field of public health. In Oriental countries, Eucommia bark (the bark of <i>Eucommia ulmoides</i>) is used in tonics and anti-hypertensive medicines. Eucommia bark has inhibitory activity against 12-<i>O</i>-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice. We demonstrated that at a dose of 1 mg/mouse, a methanol extract of Eucommia bark markedly inhibited the tumour-promoting activity of TPA in mice with skin tumour formation following initiation with 7,12-dimethylbenz[<i>a</i>]anthracene (DMBA). These results suggest the potential use of Eucommia bark in cancer prevention.<br>
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<b>Objective</b>: To show the preventive effect of dietary supplements on metabolic syndrome.<br> <b>Methods</b>: Twenty dietary supplements were examined for inhibition of α-glucosidase, absorption of sugar in mice, lipids accumulation and adiponectin production in rat visceral adipocytes.<br> <b>Results</b>: In twenty dietary supplements, Bombyx mori and mulberry leaves inhibited rat intestinal α-glucosidase more than acarbose, and inhibited absorption of sugar in mice. In visceral adipocytes, <i>Ganoderma lucidum</i>, mate and Japanese yew inhibited accumulation of lipid and Artemisia Capillaris Flowers and Ground-ivy increased production of adiponectin in rat visceral adipocytes.<br> <b>Conclusion</b>: Mulberry leaves, Bombyx mori, <i>Glechoma hederacea</i>, Artemisia Capillaris Flowers are natural products which offer promise in the prevention of diabetes and metabolic syndrome. Incorporating dietary supplements into a treatment plan with medicines with similar effects requires further study.<br>
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Chaga (the sclerotia of <i>Inonotus obliquus</i>) has been widely used as a folk medicine in the treatment of cancer, cardiovascular disease and diabetes in Russia, Poland, and several Baltic countries. More recently, this herb has been assessed for its cancer-preventing activity. Using a mouse model of skin cancer, oral administration of Chaga was found to inhibit tumor promotion by 12-<i>O</i>-tetradecanoylphorbol-13-acetate following initiation with 7,12-dimethylbenz[<i>a</i>]anthracene in mouse skin.<br>