Research progress of PARP-1 inhibitors in combination with other drugs to overcome drug resistance / 中国药科大学学报

@#Poly(ADP-ribose)polymerase-1(PARP-1)plays a vital role in the regulation of DNA repair and apoptosis. Breakthrough has been made in the treatment of cancer with PARP-1 inhibitors, but the emergence of drug resistance has limited its further application in clinic. This paper reviews advances in the research on PARP-1 inhibitors combined with other drugs to overcome drug resistance, highlights and evaluates the existing drug combination strategies and their therapeutic effects in clinical practice. It is proposed that the development of dual-target or multi-target drugs will become a promising approach to overcome the resistance of PARP-1 inhibitors and broaden their indications.

CT angiography features of the involved arterial branches of the spontaneous isolated superior mesenteric artery dissection / 中华胃肠外科杂志

<p><b>OBJECTIVE</b>To explore the CT angiography features of the involved arterial branches of the spontaneous isolated superior mesentery artery dissection(SISMAD).</p><p><b>METHODS</b>Clinical and CT angiogram data of 6 patients with SISMAD confirmed by dual source energy CT angiography were analyzed retrospectively. The CT angiography features and prognosis of patients were investigated.</p><p><b>RESULTS</b>Average age of 6 patients was(45.83±5.60) years old. Ten branches of jejunoileal artery were involved in 4 patients. All the dissections of the superior mesenteric arteries(SMA) were extended from its proximal to its end. Intramural hematoma was found in all the involved branches, which showed eccentric target sign in the transverse section and sandwich sign in the longitudinal axial section. In 7 branches of 3 patients, the involved branches originated from the false lumina of the SMA. In one patient, the intramural hematoma of the jejunoileal arteries was found to be completely absorbed in a repeated CT angiography one year late.</p><p><b>CONCLUSIONS</b>For the SISMAD, the involvement of the branches of the SMA may be associated with the extension of the dissection of the SMA. The inflation of the false lumina of the branches is worse than that of the SMA. With the improvement of the dissection of the SMA, the intramural hematoma of the branches can be absorbed. The conservative treatment may be the first choice for SISMAD without emergency.</p>

Quantitative analysis of bowel gas in patients with irritable bowel syndrome / 中华消化杂志

Objective To study the relationship between irritable bowel syndrome (IBS) and the quantity of bowel gas using plain abdominal radiographs. Methods Plain abdominal radiograph were digitized and transmitted to a computer in 48 IBS patients and 25 normal controls. The quantity of bowel gas, determined as the pixel value on images and standardized by physique, was defined as the gas volume score (GVS). The ?2s of GVS in the control group was used as the normal score. The relationship between GVS and subtype of IBS was analyzed. Results The mean GVS of normal control was 0.055?0.012, and coefficient of variation was 21.8%, and all subjects were in normal score. The mean GVS was 0.076?0.027 for the constipation type IBS, significantly higher than that for control ( t =3.599, P 0.05) and the control in the mean GVS. However, the coefficient of variation in the diarrhea type IBS was as high as 66.7%, and low score was seen in 42.9% of patients and high score in 14.3%.Conclusions There is a significant subtype related change of bowel gas volume in IBS patients. The bowel gas is increased in the constipation type, and decreased markedly in the diarrhea type.

Comparative Study of Acute Cerebral Trauma Between CT and MRI / 实用放射学杂志

Objective To compare the advantages between CT and MRI examination and to evaluate the applied value of diffusion weighted imaging(DWI) in acute cerebral trauma.Methods 54 cases with cerebral trauma were undergone CT and MRI simultaneously,the advantages and disadvantages of both examination were analysed using self-comparative method. Results In showing subarachnoid hemorrhage, ultra-acute cerebral bleeding and bone fracture,CT was better than MRI,but cerebral contusion in 5 cases,laceration of white matter in 5 cases,acute white matter swelling in 2 cases and subdural haematoma in one case were misdiagnosed by CT.DWI was much better to show laceration of white matter and acute cerebral matter swelling than CT and conventional MRI.Conclusion In diagnosing acute cerebral bleeding and bone fracture, CT is better than MRI, for other diagnoses MRI better than CT. DWI should be applied to be a common scan method in diagnose of acute cerebral trauma.