Epidemiologic features of inflammatory bowel disease in Guilan Province, North of Iran, during 2002-2012

The geographical incidence of IBD varies considerably. This study aimed to survey the epidemiologic features of IBD in Guilan province, North of Iran, during ten years duration. In this retrospective cross-sectional study, we assessed the documents of 868 patients with IBD referred to private and governmental clinics of Guilan province between 2002 and 2012. Variables such as demographic data, risk factors, diagnosis, extraintestinal manifestations and type of treatment were collected. Among 868 patients with IBD, 756 patients [87.1%] diagnosed as UC and 112 patients [12.9%] as CD. The mean age of patients with UC and CD was 46.73 +/- 15.79 and 40.15 +/- 14.27 years respectively. Male/female ratio in UC and CD was 0.92:1 and 0.75:1 respectively. The most common age of disease initiation in UC was 40-59 years and in CD 20-39 years [p<0.001]. Extraintestinal manifestations were seen in 25.4 percent of patients with IBD. Most of patients were treated with combination of two drugs: salicylates and azathioprine [p<0.04]. The incidence of IBD gradually increased during the past 4 years in Guilan province. This study showed that CD were presented significantly more common in younger patients than UC and totally the disease was slightly more common in female

[Functional assessment of mitochondrial DNA 4977 bp deletion in peptic ulcer disease]

Background and Aim: A peptic ulcer is a breach in the gastric or duodenal mucosa down to the submucosa. There is evidence concerning the role of Reactive Oxygen Species [ROS] in the genesis of such ulcers production of intracellular ROS along mitochondria oxidative phosphorylation [OXPHOS] predisposes the deletion of 4977 bp mtDNA. The aim of the present study was to evaluate the association of 4977 bp mtDNA deletion with peptic ulcer disease

Materials and Methods: In this case-control study included 110 patients with peptic ulcer disease and 110 healthy individuals were compared. Genomic DNAs of the cases and controls were extracted from bioptic tissues. Then, their genotypes were determined by means of Polymerase Chain Reaction [PCR]. Finally, statistical analysis was performed using the MedCalc program

Results: Deletion of 4977 bp mtDNA was found to be more frequent among patients with peptic ulcer disease [52.7%] compared to the controls [15.3%]. A significant association was found between the deletion with peptic ulcer disease

Conclusion: Deletion of 4977 bp in mitochondrial DNA is associated with peptic ulcer disease