Human leukocyte antigen profile of two ethnic groups in southeast of Iran

This study was performed to determine the genetic diversity of HLA class I and II alleles among two ethnic groups in Southeastern Iran. HLA profiles were determined in 71 Iranian populations [41 Zaboli and 30 Baloch]. The frequencies of HLA-A02 [p=0.017],-Cw4 [p=0.003], and-DR8 [p=0.025] in the Zaboli populations were significantly higher than that in Baloch ethnic group. In contrast, the frequency of HLA-A23 allele was more frequent in Baloch than Zaboli [p=0.020]. This report represents an important resource for investigators in the fields of transplantation immunology and population genetics from widely dispersed areas of Iran