RESUMEN
Objective: To compare the thickness of cerebello cortical gray matter of albino rats after chronic ingestion of Lithium carbonate
Study Design: Prospective experimental study
Place and Duration of Study: This study was carried out in Animal House affiliated with atomy department BMSI, JPMC, Karachi from April 2012 to June 2012
Materials and Methods: Thirty male albino rats of 100-200 grams were selected and divided into two major groups A and B. Each major group consisted of 15 animals and my study was conducted according to the time period of the study which was 2 weeks, 6 weeks and 12 weeks. The control group purpose was served by Group A which was given lab diet and B was the Lithium treated group. Lithium carbonate [ADAMJEE PHARMACEUTICALS] was given at a dose of 20mg/kg/day for 2, 6 and 12 weeks. Cerebellar Gray matter thickness was measured at 2[nd], 6[th] and 12[th] weeks in the normal healthy control group and Lithium treated group
Results: Group B showed a progressive decrement of gray matter as the time period of study advance
Conclusion: The present study concluded that Lithium carbonate causes a significant decrease of cerebello cortical gray matter
RESUMEN
Objectives: To investigate the relationship between serums resistin levels and ischaemic heart disease and severity of ischaemic heart disease
Study design: Cross sectional descriptive study
Place and duration: This study was conducted in the Department of Physiology, Basic Medical Sciences Institute [BMSI], Jinnah Post Graduate Medical Center and the National Institute of Cardiovascular Diseases [NICVD], Karachi from 1[st] September 2008 to 30[th] April 2009
Methodology: After informed consent, ninety patients with confirmed diagnosis of coronary artery disease [CAD], diagnosed on the basis of history, physical examination, classical ECG changes and raised cardiac enzymes, were enrolled and divided into 3 equal groups: 30 patients each for acute myocardial infarction [AMI] unstable angina [UA] and stable angina [SA] and 30 healthy individuals were recruited as controls. Serum resistin levels were determind by ELISA [Resistin kit by SPI bio, Bertin Pharma, France Plate reader 800, manufactured by Biotech, USA]. Complete blood count [CBC], Creatine kinase MB isoenzyme [CKMB] and Cardiac Troponin I [Trop I] were measured by standard laboratory methods
Results: Serum resistin levels were found to be increased in CAD patients and to increase in parallel with increasing severity of CAD. Serum resistin levels were also positively correlated with CKMB, Trop I and white blood cell [WBC] count
Conclusion: The results suggest that human resistin may play an important role in the pathogenesis of atherosclerosis and ischaemic heart disease