RESUMEN
The oral administration in varying doses of aqueous suspension of extract of L. alba, bark extract to rats for 10 days afforded good hepatoprotection against CCl4 induced elevation in serum marker enzymes, serum bilirubin, liver lipid peroxidation and reduction in total serum protein, liver glutathione, glutathione peroxidase, glutathione-s-transferase, glycogen, superoxide dismutase and catalase activity. The results suggest hepatoprotective and antioxidant activity of extract of L. alba bark.
Asunto(s)
Animales , Tetracloruro de Carbono/antagonistas & inhibidores , Enfermedad Hepática Inducida por Sustancias y Drogas/enzimología , Lawsonia (Planta)/química , Pruebas de Función Hepática , Extractos Vegetales/farmacología , RatasRESUMEN
The effect of feeding orally along with diet of different fractions obtained from the seeds of S. cumini was tried on fasting blood glucose and glucose tolerance in normal and alloxan diabetic rats. The quantitative determination showed that S. cumini seeds contained 40% of water soluble gummy fibre and 15% of water insoluble neutral detergent fibre (NDF). This study demonstrated that feeding for 21 days of the diets containing 15% powdered unextracted (intact) seeds containing water soluble gummy fibre, 15% powdered defatted seeds from which lipid and saponins were removed only and 6% water soluble gummy fibre isolated from S. cumini seeds significantly lowered blood glucose levels and improved oral glucose tolerance whereas feeding of the diets containing 15% powdered degummed S. cumini seeds from which water soluble gummy fibre was removed but which contained neutral detergent fibre (NDF) and 2.25% water insoluble neutral detergent fibre (NDF) isolated from S. cumini seeds neither lowered blood glucose levels nor improved oral glucose tolerance in both normal and diabetic rats. These observations indicate that the hypoglycaemic effect of S. cumini seeds was due to water soluble gummy fibre and also that water insoluble neutral detergent fibre (NDF) and other constituents of the seeds had no significant hypoglycaemic effects.