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1.
Indian J Exp Biol ; 2010 Aug; 48(8): 858-860
Artículo en Inglés | IMSEAR | ID: sea-145041

RESUMEN

Methionine-sulfoximine (MSO), a convulsant is known to increase the activity of histamine N-methyl transferase. The effect of a selective H3 receptor agonist R- ( ) methylhistamine (RAMH) and antagonist (thioperamide, THP) and some antiepileptic drugs (gabapentin and sodium valproate) have been evaluated on MSO-induced convulsions in mice. The effect of THP was also evaluated in combination with these antiepileptic drugs. Sodium valproate (300 mg/kg, po) and gabapentin (400 mg/kg, po) offered protection against MSO-induced convulsions as evidenced by a significant prolongation of latency to abnormal dorsoflexion and complete protection against mortality within 6 h of administration. THP (15 mg/kg, ip) alone and in combination with sub-effective doses of gabapentin (75 mg/kg, po) and sodium valproate (75 mg/kg, po) revealed no significant differences from the control group or either drug alone. Hence, the convulsant action of MSO does not appear to be mediated via histaminergic mechanisms.

2.
Indian J Exp Biol ; 2006 Feb; 44(2): 120-2
Artículo en Inglés | IMSEAR | ID: sea-58901

RESUMEN

Effect of 21 days administration of sertraline (30 mg/kg, po) in streptozotocin (55 mg/kg, ip) induced diabetic and non-diabetic rats produced hypoglycemia in diabetic and non-diabetic rats. Pinacidil (1mg/kg, po), when co-administered with sertraline or glimepiride antagonized the decrease in glucose levels in diabetic rats. Pinacidil (10(-6)-10(-3) M) produced dose dependent relaxation (EC50-1.58 x 10(-5) M). Neither sertraline nor glimepiride had any effect on the resting tension of ileum preparation. Both sertraline and glimepiride antagonized competitively the pinacidil-induced relaxation. The pA2 values of sertraline and glimepiride reversal of pinacidil-induced relaxation were 5.5 and 6.2 respectively. These studies suggest the involvement of K+ channels in hypoglyceimic effects of sertraline.


Asunto(s)
Animales , Diabetes Mellitus Experimental/inducido químicamente , Relación Dosis-Respuesta a Droga , Glucosa/análisis , Hiperglucemia/inducido químicamente , Hipoglucemiantes/farmacología , Relajación Muscular/efectos de los fármacos , Pinacidilo/farmacología , Canales de Potasio/fisiología , Ratas , Ratas Wistar , Sertralina/farmacología , Estreptozocina , Compuestos de Sulfonilurea/farmacología , Vasodilatación/efectos de los fármacos , Vasodilatadores/farmacología
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