Troxerutin protect sperm, seminiferous epithelium and pituitary-gonadal axis from torsion-detorsion injury: an experimental study

Background: Troxerutin is a flavonoid antioxidant that protect different organ against damage caused by ischemia-reperfusion

Objective: The aim of this study was to evaluate the effect of troxerutin in reducing the damages caused by ischemia-reperfusion in rat's testis

Materials and Methods: 40 Male Wistar rats [2 month old] were divide to four groups [n=10]. Group1 [sham], Group 2 [control, ischemia-reperfusion [I/R] without treatment], Group 3 [I/R+150 mg/kg of troxerutin], and group 4 [I/R+20 mg/kg of vitamin C]. Treatment of group 3 and group 4 during torsion [twists 720 counter clock at 90 min] followed by 50 days detorsion. After 50 days, blood samples were collected and rats in all study groups were killed and their testes were removed, and fixed with Bouin's solution. Testis was stained with hematoxylin and eosin dye and the level of testosterone, luteinizing hormone [LH] and follicle-stimulating hormone [FSH] were measured with ELISEA methods. TUNEL was employed to detect apoptosis. Epididymis caudal part was removed and total sperm count was determined. Johnson techniques were used for assessment of seminiferous tubules quality

Results: Troxerutin treated group has higher Johnson scorefs [p

Conclusion: Troxerutin has protective effects on testicular torsion induced injury and can ameliorate spermatogenesis in the torsion-detorsion models

Characteristics of colorectal cancer in khorramabad, iran during 2013

BACKGROUND: Colorectal cancer is a common, deadly disease with different incidence rates in different parts of the world. The present study aims to investigate the clinical presentations, colonoscopic findings, and family history of colorectal cancer in the city of Khorramabad, Iran

METHODS: This cross-sectional study, conducted in 2013, included 112 patients diag-nosed with colorectal cancer by colonoscopy with pathological confirmation in addition to 112 individuals matched with patients for age and gender. Controls were chosen from the outpatients admitted to the Skin and Eye Clinics of Sho-hadaAshayer Hospital in Khorramabad who had no gastrointestinal diseases. A self-generated questionnaire was used to assess family history of smoking and gastrointestinal cancer history in immediate relatives of subjects from both groups. Fisher's exact test and odds ratios [OR] were used to analyze the data

RESUETS: Based on the findings of this study, the most common clinical presentation in the patients was abdominal pain [67.9%]

The sigmoid colon [40%] was the most common anatomical site of the tumor in men; the rectum [34.6%] and sigmoid colon [34.6%] were the most common sites in women, which was not statistically significant [p=0.21]

There were 11 [19.6%] patients and 2 [3.6%] individuals in the control group who reported a history of colorectal cancer in their immediate relatives, which was statistically significant [p=0.008]

CONCEUSION: In this study, left-sided colon cancer was more common. Subjects with colon cancer had more [positive FHx. This indicated that genetic factors, in addition to environmental factors, could increase the incidence of colorectal cancer in a community. A better identification of these factors would result in better control and management of this disease

Upper gastrointestinal bleeding in Khorramabad city in 2011 a single referral center experience

Acute upper gastrointestinal bleeding [UGIB] is a common medical emergency and is known as one of the main causes of mortality and morbidity. This research was conducted to study the causes and risk factors for UGIB, in a referral center. In this cross sectional study, carried out in a one year period, all patients with acute UGIB living in Khorramabad city and surrounding area, entered the study. A control group with age and sex matched was selected from outpatient visits and their relatives who had referred to hospital clinics. Data collecting tool was a self-made questionnaire, demographic, clinical manifestations and endoscopic findings. The data was analyzed using chi-square test, Fisher exact test and Odds ratio estimation. Sixty-two patients with acute UGIB were studied, 67.7% of them were males. The mean age of patients was 54.5 +/- 12.1. The most common causes of acute UGIB were peptic [42.7%], erosive gastritis [19.8%] and esophageal varices [19.8%]. 29%, and 9.7% of patients, and control group had a history of regular consumption of Non Steroidal Anti-Inflammatory Drugs [Odd' s ratio 3.8, CI: 1.3-4.8]. 35.5% of episodes of acute UGIB were in age more than 60 years. Peptic ulcer disease is the most common cause of acute UGIB in our region. Episodes of acute UGIB were correlated with regular NSAIDs use, but not with alcohol consumption, smoking, and gender. Identifying people who are at risk and providing preventive strategies can reduce the rate of this disease and its complications

Toxoplasma infection and epilepsy: A case-control study in Iran

Epilepsy is one of the most important neurological diseases with prolonged morbidity and cerebral toxoplasmosis is one of the main cause’s aquired epilepsy in developing countries. In this study, we aimed at investigating the frequency of Toxoplasma infection among patients with cryptogenic epilepsy and the epidemiological factors associated with disease. Eighty fi ve patients with cryptogenic epilepsy and 85 healthy subjects were studied. Anti-Toxoplasma antibody status was determined in all serum samples, using ELISA technique. The frequency of Toxoplasma infection was found to be signifi cantly higher in epilepsy patients as compared to the healthy control (14.1%, 4.7%, respectively) (P=0.036). There was no signifi cant difference between cryptogenic epilepsy patients and healthy control in age, education, gender and residency (P>0.05). This study indicates that Toxoplasma infection is a risk factor for epilepsy in Iran.