Risk factors for decreased bone density in premenopausal women

Osteoporosis is a major health problem. Little is known about the risk factors in premenopause. Sixty 40-50 year old patients with regular menses were studied cross-sectionally. None of the patients were on drugs known to interfere with bone mass. Patients answered a dietary inquiry and had their bone mineral density (BMD) measured. The Z scores were used for the comparisons. A blood sample was taken for the determination of FSH, SHBG, estradiol, testosterone, calcium and alkaline phosphatase. Calcium and creatinine were measured in 24-h urine. A Z score less than -1 was observed for the lumbar spine of 14 patients (23.3 percent), and for the femur of 24 patients (40 percent). Patients with a Z score less than -1 for the lumbar spine were older than patients with a Z score ò-1 (45.7 vs 43.8 years) and presented higher values of alkaline phosphatase (71.1 + 18.2 vs 57.1 + 14.3 IU/I). Multiple regression analysis showed that a lower lumbar spine BMD was associated with higher values of alkaline phosphatase, lower calcium ingestion, a smaller body mass index (BMI), less frequent exercising, and older age. The patients with a Z score less than -1 for the femur were shorter than patients with a Z score ò-1 (158.2 vs 161.3 cm). Multiple regression analysis showed that a lower femoral BMD was associated with lower BMI, higher alkaline phosphatase and caffeine intake, and less frequent exercising. A lower than expected BMD was observed in a significant proportion of premenopausal women and was associated with lower calcium intake, relatively lower physical activity and lower BMI. We conclude that the classical risk factors for osteoporosis may be present before ovarian failure, and their effect may be partly independent of estrogen levels.

Listeriose como causa de morte fetal: relato de um caso. / Listeriosis as cause of fetal death: report of a case

Apresentacao de revisao sucinta de listeriose com maior enfase na sua importancia na gestacao. Relato de caso de listeriose descoberta em paciente internada no Hospital Universitario da PUC com quadro de trabalho de parto prematuro.Quando da baixa o concepto estava vivo. O obito fetal ocorreu durante a internacao obstetrica. E descrita a rotina de investigacao sorologica e bacteriologica