Effect of myosin B on guinea pig muscles--light microscopic and immunological aspects.

Experimental myositis was induced in guinea pigs by multiple inoculations with Myosin B fraction of the rabbit skeletal muscle. Quantitative histopathological features were studied and they include necrosis, central nucleation, inflammatory cellular reaction. Besides myositis, features of myocarditis were evident in 40% animals. Circulating immune complexes (CICs) in the sera of experimental animals were isolated by a polyethylene glycol (PEG) precipitation method. Presence of antimyosin B antibody in the immune complexes was characterised by an enzyme-linked immunosorbent assay. The role of circulating immune complexes in pathogenesis of experimental myositis and human polymyositis have been emphasised.

Primary Ewing's sarcoma of the base of skull: a case report.

Primary cranial Ewing's sarcoma is an exceptionally rare lesion and only eleven cases have so far been reported. In this report we describe a case of primary Ewing's sarcoma arising from the floor of middle cranial fossa. Salient clinical, neuroradiological and light microscopic features in this case are described. A brief review of earlier published cases of primary cranial Ewing's sarcoma are also presented.

Epidermoid cyst of the brain stem--a case report.

Epidermoid cysts occurring within the brain stem are extremely rare and only nine such cases are reported in the literature. In this report, we report a case of Intrapontine epidermoid cyst in a young female patient.

Humoral immune reactions in tuberculous meningitis.

Humoral immune reactions as reflected in sera and cerebrospinal fluid (CSF) of 50 patients with Tuberculous meningitis (TBM) were studied. CSFs and sera from 50 patients with nontuberculous neurological diseases were selected as controls. CSFs of patients with TBM showed high titres of circulating antimycobacterial antibodies than in nontuberculous subjects. The CSF-IgG index is significantly higher in patients with TBM. Humoral immune reaction could be applied in the laboratory diagnosis of TBM, particularly when repeated bacteriological methods are negative for M. tuberculosis in CSFs.