Strain improvement studies on production of cephalosporin C from Acremonium chrysogenum ATCC 48272.

Strain development for antibiotic production has been an essential prerequistie for efficient production process. Studies were carried out to produce high antibiotic yield strain by using UV and N-methyl-N1-nitro-nitrosoguanidine (NTG) as mutagens. A superior mutant (PNTG-22) with a productivity of 2.4 time (810-1995 microg/ml higher than, the parent strain was produced.

Characterisation of a new bioactive actinomycete AUB N5/8 from marine sediments.

Actinomycetes were isolated from marine sediments off Machilipatnam coast of Andhra Paradesh by plating on Starch-Casein Agar medium. From which one isolate AUB N5/8 was selected for detailed morphological, cultural, physiological and biochemical studies. The genera encountered were, Streptomycetes. Studies were compared with known strain S. baarinenisis (ISP 5232). It showed enough significant difference to create the status of a separate species for our isolate AUB N5/8. Hence it was designated as Streptomyces kavutarensis Sp.nov.