Antiplatelet and Antithrombotic Effects of the Extract of Lindera obtusiloba Leaves

Lindera obtusiloba has been used in traditional herbal medicine for the treatment of blood stasis and inflammation. The leaves of Lindera obtusiloba have been reported to exhibit various physiological activities. However, there is little information available on their antiplatelet and antithrombotic activities. Thus, the present study aimed to evaluate the effect of Lindera obtusiloba leaf extract (LLE) on platelet activities, coagulation and thromboembolism. In a platelet aggregation study, LLE significantly inhibited various agonist-induced platelet aggregations in vitro and ex vivo. Furthermore, LLE significantly inhibited collagen-induced thromboxane A2 (TXA2) production in rat platelets. In addition, oral administration of LLE was protective in a mouse model of pulmonary thromboembolism induced by intravenous injection of a mixture of collagen and epinephrine. Interestingly, LLE did not significantly alter prothrombin time (PT) and activated partial thromboplastin time (aPTT). This study indicates that the antithrombotic effects of LLE might be due to its antiplatelet activities rather than anticoagulation. Taken together, these results suggest that LLE may be a candidate preventive and therapeutic agent in cardiovascular diseases associated with platelet hyperactivity.

A study on the contact angle and wettability of the dental stones / 대한치과보철학회지

The purpose of this study was to investigate the contact angles and wettability of conventional dental stones and improved dental stones and newly developed dental stones on several impression materials. Materials included in this study were several dental stones and newly developed dental stone; 2 type III stones (Snow Rock, New Diastone), 6 type IV stones(Crystal Rock, Vel Mix, Fuji Rock, Tuff Rock, Resin Rock and newly developed dental stone) and 1 type V stone (Die Keen). Contact angles on the impression materials were measured with contact angle measuring device. Ten specimens for each material, total 180 specimens were made on void entrapment model. The two impression materials (Handae, GC) were used to produce 9 groups of die stone casts form void entrapment model. Voids in the stone casts were counted under a stereoscopic microscope. The grad for the reproduction ability of each materials on the void entrapment model was calculated from the casts by one examiner. From the experiment, the following results were obtained : 1. The newly developed stones showed smallest contact angle. Type III dental stone had larger contact angles than type IV and V stones. Contact angle was much affected by the impression materials. 2. Resin containing die materials such as Tuff Rock and Resin Rock had smallest void number than any other groups. 3. In comparing reproduction parameters, Tuff Rock and Resin Rock presented superior results, while Vel Mix showed lowest reproduction ability.

A Study on the Abrasion Resistance and Surface Roughness of the Dental Stones / 대한치과보철학회지

The purpose of this study was to investigate the abrasion resistance and surface roughness of conventional dental stones and improved dental stones and newly developed dental stones. Materials included in this study were several dental stones and newly developed dental stone; 2 type III, 6 type IV(including newly developed dental stone),1 type V Ten specimens for each material,total ninety specimens were made. Each specimen was subjected to 50 complete cycle abrasion under constant load 0.42N at speed of 6mm per sec.The depth after abrasion test was measured for each specimen. Surface roughness before and after abrasion test was compared.The results were as follows ; 1.The resin containing die materials such as Tuff Rock and Resin Rock had superior abrasion resistance. 2.Type IV,V Surface roughnessdental stone exhibited greater abrasion resistance than Type IIIdental stone. 3.The results of the surface roughness showed similar pattern with the abrasion resistance.

Ankle Ligaments: Comparison of MR Arthrography with Conventional MR Imaging in Amputated Feet

PURPOSE: To compare magnetic resonance (MR) arthrography with conventional MR imaging in the evaluation of ankle ligaments. MATERIALS AND METHODS: Eight freshly amputated human feet underwent conventional MR imaging and MR arthrography. For the former, 1.5-T magnets in the axial, coronal and sagittal planes were used, and T1-weighted sequences were obtained. Following the injection of 6 -10 ml of diluted contrast media (Gd-DTPA 1:250), T1-weighted images were obtained in the same positions as conventional MR images. Paired conventional MR imaging and MR arthrography of each ankle ligament were rated on a five-point scale, and to reflect inter-group differences a Wilcoxon singed-rank test was used to compare the different measurements (p<0.05). In two ankles, MR images of the ligaments were correlated with ankle dissection. RESULTS: Anterior and posterior talofibular ligaments were more clearly revealed by MR arthrography than by conventional MR imaging, while calcaneofibular ligaments showed no difference between these two modalities. With regard to deltoid ligaments, visualization of the anterior and posterior tibiotalar ligament was much improved when contrast material was used to outline the ligament's articular aspect. Visualization of the posterior inferior tibiofibular ligament and inferior transverse ligament were also improved when the use of contrast material provided delineation of the articular side of the ligaments and separated them from adjacent bone. In addition, MR arthrography was very useful for identification of the posterior intermalleolar ligament, though its use did not enhance visualization of the calcaneofibular, tibiocalcaneal, spring or tibiospring ligaments. CONCLUSION: MR arthrography accurately revealed the anatomic details of ankle ligaments, and may therefore be more useful than conventional MR imaging for evaluation of these structures.

WETTABILITY OF POLYVINYLSILOXANE IMPRESSION MATERIALS AND IMPROVED STONE MATERIALS / 대한치과보철학회지

Wettability of addition silicone impression material is very important property for making an accurate restoration. This study examined the impression quality in clinical condition and the wet tability of impression and die material. Four commercially available addition silicone impression material (Express, Examix, Contrast, Perfect) and three die materials (Die-Keen, Vel-Mix, FujiRock) were studied. A total of 50 putty/wash and heavy body/wash impressions of wet intact permanent molar teeth were examined for definition of the gingival sulcus reproduction and then classified in quality ranking. The percentage of the sulcus reproduction ability of each material was calculated from the sulcus depths of cross-sectioned epoxy resin casts from the impressions and clinically measured sulcus depths. The same impression materials were used to produce 3 groups of die stone casts form void entrapment die had been exposed to milk. Voids in the impression. body and stone casts were counted under a stereoscopic microscope. From the experiment, the following results were obtained 1. Sulcus reproduction ability of additional silicone impression material were diminished in order of Express, Examix, Perfect, Contrast. The significant difference was found between Perfect and other material. Heavy body/wash combination was superior to putty/wash method in Perfect impression material. 2. In direct observation, bontrast showed least void in impression body but correlations were not found between sulcus reproduction and void production. 3. In void entrapment laboratory test, wettability were diminished in order of Examix, Contrast, Express, Perfect. Clinical impression recording seems not to correlate with laboratory test. 4. The wettability of die material to impression material was not different in Express, Examix, Contrast. But, in Perfect, Die-Keen had superior wettability to others.

Congenital Bronchial Atresia Coexistent with Intralobar Pulmonary Sequestration: A Case Report

Bronchial atresia coexistent with intralobar pulmonary sequestration is so rare that only two cases have been reported in the literature. We report a case of congential bronchial atresia coexistent with intralobar pulmonary sequestation in a 51 year-old woman. Computed tomography showed the branching mass with hyperinflation of adjacent pulmonary parenchyma in the medial segment of the right middle lobe and a large thin-walled cystic mass with air-fluid levels in the medial basal segment of the right lower lobe. Selective inferior phrenic arteriography showed two aberrant arteries supplying the large cystic mass in the right lower lobe. The venous drainage was through the right pulmonary vein.

Removal of Esophageal Foreign Body: Fluoroscopic Guided Double Balloon Technique

PURPOSE: To assess the efficiency of a fluoroscopy-guided double balloon technique in removal of esophageal foreign bodies. MATERIALS AND METHODS: Seven patients with esophageal foreign bodies were treated by fluoroscopy-guided double balloon technique. They suffered from dysphagia. Foreign bodies were meats(n=3), a pig bone, a beef bone, a tablet, and a chinese cabbage leaf. Three patients had underlying diseases:corrosive stricture (n=2) and postoperative stricture(n=1). Double balloon technique for removal of the foreign bodies was performed by trapping a foreign body with two valvuloplasty balloons under fluoroscopic guidance. After removal of a foreign body, stricture sites in three patients were dilated by single balloon. RESULTS: Foreign bodies were removed successfully in all patients with improvement of symptoms. Three patients with stricture were successfully treated by single balloon dilatation. There was no complication with the procedure. CONCLUSIONS: Removal of esophageal foreign bodies with fluoroscopically guided double balloon technique is effective and promising alternative to esophagoscopic removal. In addition, balloon technique is effective in the treatment of underlying esophageal stricture.

Adult presentation of congenital cystic adenomatoid malformation of the lung: a case report

Adult presentation of congenital cystic adenomatoid malformation(CCAM) of the lung is so rare that only 5 cases have been reported in the literature to date. We report the case of a 19-year-old female with CCAM in the left lower lobe. Computed tomography showed a multilobulated cystic lesion with multiple air-fluid levels and also showed focal enhancement of the solid component in the eccentrical portion of the lesion. Thoracic aortogram and selected bronchial arteriograms show a slightly enlarged and tortuous bronchial artery feeding the multilobulated cystic lesion. We present the clinical and radiological features of our case with a brief review of the literature.

Expandable Metallic Stent in the Treatment of Subglottic Tracheal Stenosis: Report of Long-term Failure in 4 Cases

Subglottic stenosis is more likely to develop secondary to endotracheal intubation if one or more traumarelated risk factors are involved. Subglottic stenosis have been dealt with many medicosurgical procedures such as dilatation, stent, laryngofissure with or without skin of mucosal graff, and segmental resection. We report longterm failure of expandable metallic stent in the treatment of subglottic tracheal steno$is in 4 cases which had been presented with respiration difficulty due to framework problem of subglottic trachea after surgical operation.

A Clinical Study on 98 Cases of Purpura / 대한피부과학회지

A clinica1 study was carried ou on the 98 cases of purpura who were admitted to the Han Gang Sung Shim Hospital during the period of 3 years from Sept., 1975 to Aug., 1978. The results were as follows: 1. The most common cause of purpura was allergic purpura (35.7%). 2. The highest incidence was under 10 years of age group(63.3%), and males were more frequently affected tban fomal with the ratio of 1.3: l. 3. The saonal incidence of purpura was high during the period of 5 months fror Jan. to Klay. Especially in the allergic purpura high incidence was seen in April, May and October. 4. The preclilection site of purpura was on the lower extremities (87.5%) Especially in allergic purpura, the purpura lesions were occured on the lower extremities in all cases. 5, Platelet count in allergic purpura was normal, and that of L.T.P., leukemia, menigococcemia, aplastic anemia and sepsis was decreased in mostly all cases. 6. Bleeding; time was normal in allergic purpura, hut prolonged in ahout 50% of otber diseases. Coagulation time was normal in all cases. 7. Occuit blood was positive in 40% of all cases. 8. Renal rnan!festations occured in 37 cases(37.8%). The most common among them was proteinuria(89.2%)