Clinicopathological Study of Cutaneous Involvement from Breast Cancer / 대한피부과학회지

BACKGROUND: Cutaneous involvement from breast cancer is rarely seen in dermatologic clinics although the breast is the most common source of cutaneous metastasis in women. OBJECTIVE: Our purpose was to study the clinical and histopathological characteristics of cutaneous involvement from breast cancer in our hospital. METHODS: A clinical and histopathological observation was made analyzing 42 cases of cutaneous involvement from breast cancer during the last 13 years from 1990 to 2002 in Asan Medical Center. RESULTS & CONCLUSION: The mean age at diagnosis of breast cancer was 45.8 years. The most common histologic type was infiltrating ductal carcinoma(39 cases), followed by infiltrating lobular carcinoma(1 case) and malignant cystosarcoma phyllodes(1 case). The patterns of cutaneous manifestations were nodular(22 cases), lymphadenopathic(10 cases), inflammatory(5 cases), indurated(3 cases), and zosteriform(2 cases). The sites of locoregional recurrence(LRR) were as follows: the chest wall(28 cases), the ipsilateral supraclavicular node(8 cases), the axillary node(2 cases). The sites of distant skin metastasis were as follows: the contralateral chest wall(6 cases), the scalp(5 cases), the arm(3 cases), the abdomen(1 case), the finger(1 case). LRR or distant skin metastasis appeared within the first decade after treatment in all patients.

Clinicopathological Study of Cutaneous Involvement from Breast Cancer / 대한피부과학회지

BACKGROUND: Cutaneous involvement from breast cancer is rarely seen in dermatologic clinics although the breast is the most common source of cutaneous metastasis in women. OBJECTIVE: Our purpose was to study the clinical and histopathological characteristics of cutaneous involvement from breast cancer in our hospital. METHODS: A clinical and histopathological observation was made analyzing 42 cases of cutaneous involvement from breast cancer during the last 13 years from 1990 to 2002 in Asan Medical Center. RESULTS & CONCLUSION: The mean age at diagnosis of breast cancer was 45.8 years. The most common histologic type was infiltrating ductal carcinoma(39 cases), followed by infiltrating lobular carcinoma(1 case) and malignant cystosarcoma phyllodes(1 case). The patterns of cutaneous manifestations were nodular(22 cases), lymphadenopathic(10 cases), inflammatory(5 cases), indurated(3 cases), and zosteriform(2 cases). The sites of locoregional recurrence(LRR) were as follows: the chest wall(28 cases), the ipsilateral supraclavicular node(8 cases), the axillary node(2 cases). The sites of distant skin metastasis were as follows: the contralateral chest wall(6 cases), the scalp(5 cases), the arm(3 cases), the abdomen(1 case), the finger(1 case). LRR or distant skin metastasis appeared within the first decade after treatment in all patients.

Eruptive Syringoma: Clinicopathologic Analysis of Thirteen Cases

BACKGROUND: Eruptive syringoma is a very rare variant of syringoma and arises most frequently on the anterior trunk of young people. Because eruptive syringoma represents clinically a very rare distinct entity, clinicopathologic studies rarely have been described in literature. OBJECTIVE: The aim of this study is to characterize clinical and histopathologic findings of eruptive syringomas which were diagnosed by histopathologic examination for a 10 year period in Asan medical center. METHODS: The hospital records, clinical history, and biopsy slides of 13 eruptive syringoma were reviewed retrospectively. RESULTS: There were 5 men(38%) and 8 women (62%) with the mean age of 31 years. The mean age of onset was 23 years and 3 patients(23%) presented the lesions before puberty. The most frequently involved sites were anterior trunk, axilla, upper extremities, neck, and face in descending order. The most common initial clinical diagnosis was verruca plana(38%). Most of the lesions did not show self-limiting course and several treatment modalities including oral isotretinoin or CO2 laser were not so effective. All cases showed characteristic histopathologic features of syringoma and 76% of them revealed increased basal melanin pigment or pigmentary incontinence. CONCLUSION: Eruptive syringoma should be included in the differential diagnosis of flat papular lesions by histopathologic examination and it may help to avoid inappropriate therapeutic approach.

A Case of Hair Follicle Nevus / 대한피부과학회지

Hair follicle nevus is a very rare hair follicle tumor and should be differentiated from other hair follicle hamartomas, such as trichofolliculoma, dilated pore of Winer, pilar sheath acanthoma, and trichodiscoma. We describe a 4-year-old female patient who presented erythematous papule on the face that was histopathologically diagnosed as hair follicle nevus.

A Case of Epidermolytic Palmoplantar Keratoderma / 대한피부과학회지

Palmoplantar keratodermas are divided into autosomal dominant and autosomal recessive groups by the mode of transmission. The autosomal dominantly transmitted group is further divided into epidermolytic and nonepidermolytic types according to the histological findings. Hereditary epidermolytic palmoplantar keratoderma manifests clinically as a localized thickening of the palms and soles. Herein we report a 29-year-old woman showing the typical clinical and histologic features of epidermolytic palmoplantar keratoderma without family history. This case could be spontaneous mutations that will later breed a true autosomal dominant trait.

A Case of Benign Symmetric Lipomatosis

Benign symmetric lipomatosis is characterized by diffuse symmetric deposits of nonencapsulated fat, generally affecting the cervical and upper dorsal regions. There is a history of alcohol abuse in nearly all the cases. It is rarely reported in non-drinkers. Herein we report a 63-year-old man presenting with one year's history of multiple ill-defined symmetric soft mass on posterior neck, upper trunk and upper extremities without the history of alcohol abuse. We ad-ministered corticosteroid orally due to osteoarthritis of the knee for a long time.

A Case of Guttate Psoriasis in the Recipients of Allogeneic Bone Marrow Transplantation / 대한피부과학회지

In many studies, it has been demonstrated that donor-derived cells would eventually replace the hematopoietic and immune system of the recipient after allogeneic bone marrow transplantation (BMT). And there are several case reports describing resolution or development of autoimmune diseases after BMT. Psoriasis is considered to be an autoimmune disease of abnormal keratinocyte proliferation induced by T lymphocytes. Herein we describe a 17-year-old woman presenting with guttate psoriasis, who suffered from acute lymphocytic leukemia and underwent allogeneic BMT 6 months ago. This is the first case of guttate psoriasis possibly associated with BMT in the Korean literature.

A Case of Verruciform Xanthoma on the Scrotum / 대한피부과학회지

Verruciform xanthoma is a rare benign skin or mucosal lesion characterized by verrucous epithelial proliferation accompanied by a prominent replacement of the dermal papillae with foamy histiocytes. The majority of the cases occur on the oral mucosa, but other sites, particularly the genital region, may be involved. Genital verruciform xanthoma can simulate other benign or malignant skin conditions. We describe a 68-year-old man who presented yellow to skin-colored verrucous nodule on the scrotum of which histopathologic findings showed characteristics of verruciform xanthoma.