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Mem. Inst. Oswaldo Cruz ; 93(2): 215-7, Mar.-Apr. 1998. graf
Artículo en Inglés | LILACS | ID: lil-203601

RESUMEN

Cold acclimatization (4-5ºC) is accompanied by 2-3 fold increase of brown adipose tissue (BAT). This rapid growth of interscapular BAT was studied after histamine depletion. In control rats maintenained at room temperature (28 ñ 2ºC) the BAT histamine content was 23.4 ñ 5.9 (mean ñ SD) µg/g of tissue and cold acclimatization (5 ñ 1ºC) produced a signifacant increase of BAT weight, but reduced the histamine content to 8.4 ñ 1.9 µg/g. The total weight of BAT after 20 days of acclimatization was unaffected by depletion of histamine due to compound 48/80. The low level of histamine in BAT of cold acclimatization rats could be a fast rate of amine utilization; alternatively and altered synthesis or storage process may occur during acclimatization.


Asunto(s)
Animales , Ratas , Tejido Adiposo Pardo/crecimiento & desarrollo , Histamina , Mastocitos , p-Metoxi-N-metilfenetilamina
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