RESUMEN
Background: glucantime is regarded as the first line in the treatment of cutaneous leishmaniasis, but failure to treatment is a problem in many cases. óEvaluation of glucantime activity in the cutaneous leishmaniasis complicated with secondary bacterial infection compared with uncomplicated lesions
Materials and Methods: this experimental clinical trial Patients enrolled in the study had cutaneous leishmaniasis. The lesions were scraped with sterile swap and cultured into the blood agar medium. All the patients were treated with systemic glucantime for 3 weeks and followed for 2months. Response to treatment was defined as loss of infiltration, re epithelization and negative smear, and unresponsiveness defined as unchanging the size of the lesions without re epithelization and positive smear at the end of the study. Regarding to results of cultures, the lesions were divided into two groups with positive and negative cultures and glucantime activity was compared between two groups
Results: out of 161 patients enrolled in the study, 123 [76.4%] were Negative and 38 patients [23.6%] were Positive for secondary bacterial infection. In groups with negative bacterial culture response to treatment was 65 % [80 Patients] and in the other group was 31.6% [12 patients] [X2= 13.77, P<0.01]
Conclusion: activity of glucantime decreased in cutaneous leishmaniasis lesions with secondary bacterial infection