[Solitary fibrous renal tumor: a case report and review of the literature]

Solitary fibrous tumors are mescenchymal neoplasms which develop from connective tissue. They rarely occur in the kidney and to our knowledge only 11 cases have been reported in the literature so far. We herein report a solitary fibrous tumor of the Kidney in a 60-year-old patient presenting with renal colic. CT scan revealed a tumor in the renal hilum. The patient was subjected to total nephrectomy, and histological examination of the excised tissue showed fusiform cellular fibrotic proliferation. Immunohistochemistry confirmed the diagnosis by showing positive CD 34 and bcl-2 markers

[ auto antibodies: a diagnostic tool in systemic diseases]

The auto antibodies constitue an important diagnostic tool in the auto-immune diseases, their rates do not correlat with the activity of the disease except for a little number among them. The interest of the research of the auto-antibodies is objectified in: - the positive diagnosis and the different relationships to the systemic diaseases. - the differential diagnosis of the systemic diseases. - the evolution and the prognosis of these affections according to the title or the type of the auto-antibody. The antinuclear antibodies means all the autoantibodies directed against structures of the nucleus. Ang research of antinuclear antibodies starts with tracking, followed by analysis, to identify all or a part of the recognized antigens. After the definition of the antinuclear antibodies and their different specifications as well as their techniques of detection, we are going to review the main systemic diseases, explaning direct interrelationship with different types of auto-antibody

Urticarial vasculitis revealing a lupus like syndrome

We report the case of a 38 years old woman with urticarial cutaneous lesions associated with multiple systemic involvemernt including arthralgias, myalgias, muscular weakness, persistant hypocomplementemia is noted. A biopsy of the urticaria demonstrated a leucocytoclasic vasculitis, the immunofluorescence study of the skin biopsy showed IgM, C3 and C1q deposits in the dermo epidermal junction and along the capillary wall. Antinuclear antibodies, anti DNA are present. The syndrome recognized in this patient and those few observations reported previously constitue a lupus like syndrome

macrophage hyperactivation syndrome with hemophagocytosis

The hemophagocytic syndrome is a benign systemic histiocytic proliferation which may be caused by several etiologies: infections, autoimmune diseases, hemopathy; << solid >> cancers, immunity deficits. The inadequatee activation of the loop << macrophage - lymphocyte >> with hypercytokinemia explain in the large proportion the physiopathological, clinical and biological features. This syndrome includes: fever, organomegaly, cytopenia, hypertriglyceridemia, hyperferritinemia and clotting disorders. The diagnosis is based on clinical, biological and especially histopathological criteria: with tissue and/or medullary histiocytic infiltration. We report two cases of hemophagocytic syndrome in which the etiology had remained undetermined and the evolution had been fatal