RESUMEN
Clinical examination and Laboratory investigations done to IS male type I chronic diabetic patients [insulin dependent more than 5 years] and to an age mached group of 10 normal male volunteers revealed normocalcaemia and normomagnesaemia with significant hyperphosphataemia. Estimation of serum level of parathormone showed significant hypoparathyroidism. An addition, significant hypercalcuria, hyperphosphaturia and hpermagnes uria were also detected. Histopathological examination of trabecular bone biopsies from both groups revealed marked osteoportic changes among the diabetic patients. Biochemical analysis of similar bone samples supported the microscopic findings by demonstrating significant decrease of calcium contents of the bone in the diabetic group. In the chronic rats [7 weeks after streptozotecin induction] significant hypercalcaemia, hyperphosphataemia and normomagnesaemia were found. Their sera showed significant hypoparathyroidism. In addition, significant hypermagnesuria. Histopathological examination of the rat's right tibiae revealed advanced rachitic changes. Biochemical analysis of the left tibias approved the microscopic findings by showing significant decrease in bone calcium contents
Asunto(s)
Humanos , Animales de Laboratorio , Enfermedad Crónica , Hipoparatiroidismo , Diabetes Mellitus Experimental , Calcio/sangre , Calcio/orina , Hormona Paratiroidea , Tibia/patología , Histología , RatasRESUMEN
The immediate effect of salbutamol on forced vital capacity, peak expiratory flow rate, maximal flow rate, airway resistance and intrathoracic gas volume was studied in forty-six asthmatic patients. There was significant increase in the forced vital capacity, peak expiratory flow rate and maximal expiratory flow rates, while there was significant decrease in the airway resistance and intrathoracic gas volume. A remarkable observation on the response to salbutamol in different age groups was seen. Patients up to forty years of age showed high significant increase in the maximal expiratory flow rates [especially V[max]50] in-spite of low significant decrease in the total airway resistance. The patients above forty years showed insignificant change in the maximal expiratory flow rates despite the high significant reduction in their airway resistance. This observation was attributed to the change in the elastic recoil properties of the lung with age and/or long standing asthma. It can also be attributed to irriversible narrowing of the small airways in old patients with long standing asthma
Asunto(s)
Pruebas de Función Respiratoria , Asma , Factores de EdadRESUMEN
Thirty women receiving Gyn-Anovlar were studied for plasma cortisol level. Ten of them were examined before and after Gyn-Anovlar therapy for basal cortisol and were injected intramuscularly with 250 mg mg of Synacthen. There was a significant rise of plasma cortisol and the patients responded normally to the injection of Synacthen indicating a good adrenal reserve function. The remaining 20 patients were already taking the pills for periods ranging from 8 to 9 months. Their plasma cortisol level was not statistically different from those taking the pills for six months