RESUMEN
Objective In order to observe the dispersing form, the sustained release solid dispersion was prepared. Methods Sustained-release solid dispersion was prepared by taking ethyl cellulose as carrier. And the X-ray diffraction, differential scanning calotimetery (DSC) were used to evaluate the dispersing form of puerarin in the preparation and to study the solubility in vitro. Results The X-ray diffraction experiment showed that the puerarin was existed in molecuar and minicrystal form. DSC Experiment showed that there is no puerarin crystal in the solid dispersion. The test for stripping showed that thare was a better releasing results in the sustained-release capsula. Conclusion The sustained-release solid dispersion can disperse the puerarin highly to increase its bioavailability. The prepared capsula has a marked sustained-release effect.
RESUMEN
AIM: In order to prolong release time and increase bioavailability of puerarin,the sustained release solid dispersion was prepared.METHODS: Sustained-release capsules were prepared by solid dispersing technology.And the dissolution in vitro of pueriarin and excipients that affect the dissolution were studied. RESULTS: Dissolution of pueriarin solid dispersion was affected by kinds of ethyl cellulose(EC);With the increase of the EC-puerarin ratio,the releasing speed of pueriarin becoming slowly.And the release rate conformed to apparent zero-order kinetics.The releasing effect could be adjusted by adding releasing-regulator HPMC. CONCLUSION: The prepared puerarin capsule has a marked sustained-release effect.