Determination of albendazole as raw material and in tablets by nonaqueous titration with sodium methylate solution

Albendazole is a broad-spectrum benzimidazole anthelmintic recently introduced in the pharmaceutical market. A new volumetric dosage method is proposed, in nonaqueous medium with sodium methylate using DMF as eluent, for albendazole analytical determination as raw material and in tablets. The equivalence point was obtained exactly with the potentiometric method using the second derivative. The method is simple and accurate with a sensitivity limit< '10 POT.-5'M.