RESUMEN
Objective: To investigate the relationship of TNF-A-863 and CGRP979 gene polymorphisms with the susceptibility to severe chronic periodontitis in Chinese. Methods: Buccal swabs were collected from 100 adult patients with severe chronic periodontitis and 118 healthy adult controls. DNA was extracted from each subjects of the two groups. PCR-LDR technique was used to identify the genotypes of TNF-A-863 and CGRP979. The difference in the genotypes between the two groups was analyzed by statistics software. Results: The genotype of TNF-A--863 was mainly TNF-A-863 A/C in patients with severe chronic periodontitis and TNF-A-863 C/C in healthy controls. There were significant differences in TNF-A-863 distribution between the two groups( P<0.05). We also found that there were significant differences in genotype distribution of CGRP979 between the two groups (P<0.05) ,with A/C predominating in patients with severe chronic periodontitis. Condusion: TNF-A-863 polymorphism is associated with severe chronic periodontitis; A/C of the CGRP979 loci might be a factor for severe chronic periodontitis.