RESUMEN
This paper introduced an experimental study of the preparation of polylacticacid (PLA) nanoparticles of cucurbitacin (CuC) using a precipitation method. The residual acetone, ratio of CuC PLA precipitates, and the relationships between the ratios of two precipitates and drug incorporation rates were measured. It appeared that the nanoparticles with 60% of PLA incorporated with 5.5% of CuC were formed when acetone was injected into the aqueous phase. As the acetone gradually evaporated, drug incorporation/encapsulation continued, with most of CuC (about 70%) formed new crystalline cores and suspended in the form of microcrystals in the medium, resulting a suspension containing both nanoparticles and microcrystals. We also concluded that this system may not necessarily be suitable for all lipophilic drugs to be prepared to PLA nanoparticles with good incorporation rate. The drug incorporation depended on the interactions among drug, PLA, and organic solvents, in addition to the solubility of the drug.
Asunto(s)
Antineoplásicos Fitogénicos , Precipitación Química , Cucurbitaceae , Química , Cucurbitacinas , Preparaciones de Acción Retardada , Composición de Medicamentos , Métodos , Sistemas de Liberación de Medicamentos , Ácido Láctico , Microesferas , Nanotecnología , Tamaño de la Partícula , Plantas Medicinales , Química , Poliésteres , Polímeros , TriterpenosRESUMEN
<p><b>OBJECTIVE</b>To purify the extract of fructus gardeniae for injection by macroreticular resins in purification process of traditional Chinese medicine (TCM) Injections.</p><p><b>METHOD</b>Using fructus gardeniae as sample, on base of obtaining the extract by employing macroreticular resin, quality evaluation and rationality of purification methods had been studied by the quantitative analysis of active ingredients and the characteristics of micromeritics, safety and stability of the extract.</p><p><b>RESULT</b>The experiment showed the extract of fructus gardeniae for injection had been produced successfully by macroreticular resin.</p><p><b>CONCLUSION</b>Using macroreticular resins is a promising purification way of TCM injections, whereas a more consummate method of quality evaluation must be established to ensure safety, efficiency and stability of the preparation in the process.</p>