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Chinese Journal of Experimental and Clinical Virology ; (6): 443-445, 2009.
Artículo en Chino | WPRIM | ID: wpr-325517

RESUMEN

<p><b>OBJECTIVE</b>To investigate the expression feature of peroxiredoxin III in cervical lesions and to further understand the mechanism for cervical cancer development/progression.</p><p><b>METHODS</b>Expression of peroxiredoxin III was immunohistochemically detected in cervical cancer. In addition, cervical epithelia were transfected with recombinant adeno-associated virus vector containing human papillomavirus 16 E6/E7 and peroxiredoxin III expression was detected by quantitative real time PCR and Western blotting.</p><p><b>RESULTS</b>Peroxiredoxin III was significantly up-regulated in cervical cancer tissues. Nevertheless, expression of peroxiredoxin III remained unchanged in cervical epithelial cells after transfection.</p><p><b>CONCLUSION</b>It seems that Prx III is not related to cervical cancer initiation. Up-regulation of peroxiredoxin III in cervical cancer might be an active response to oxidative stress in malignant cells, which protects against oxidatiton-induced apoptosis.</p>


Asunto(s)
Femenino , Humanos , Persona de Mediana Edad , Cuello del Útero , Metabolismo , Regulación Neoplásica de la Expresión Génica , Papillomavirus Humano 16 , Genética , Metabolismo , Proteínas Oncogénicas Virales , Genética , Metabolismo , Proteínas E7 de Papillomavirus , Genética , Metabolismo , Peroxirredoxinas , Genética , Metabolismo , Proteínas Represoras , Genética , Metabolismo , Regulación hacia Arriba , Neoplasias del Cuello Uterino , Genética , Metabolismo , Virología
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