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Objective To study the constitutes of thyroid diseases suffered surgical treatment,and sumup the therapeutic effect.Methods The clinical data of 426 patients with thyroid diseases who suffered surgical treatment.Results Thyroid diseases suffered surgical treatment increased significantly.Most diseases of this group were nodu largoiter(59.9%)and thyroid carcinoma(16.6%).Hyperthyroidism treated by operation was decreasing(P＜0.01),but hashimotos thyroiditis was increasing(P＜0.05).The primary operative modes were total thyroid lobectomy(21.3%)if thyroid benign diseases were localized in one lobe of thyroid.The most operative program of thyroid carcinoma was total affected lobectomy plus is thmus and oppositesub total lobectomy.The prophylactic neck dissection was not suggested.The leading an esthetic modes were general anesthesia.The incidence of operative complications was 4.0%,including postoperative hemorrhage 0.5%,injury of recurrent laryngeal nerve 0.7%,injury of superior laryngeal nerve 0.9%,permanent injury of para-thyroid 0.2%,hypothyroidism 0.9%,hyperthyroidism crisis 0.2%and operative mortality 0.2%.The rate of post operative recurrence was 2.2%,which had decreased several years late(P＜0.05).Conclusions The operation modes should be individualized in light of the lesion pathology,location,size and the situation of lymph metastasis.The measures for reducing the incidence of operative complications are effect.
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Objective To study the curative effect of breast-conserving therapy in patients with breast cancer.Methods 100 cases with breast cancer were divided into breast-conserving therapy 50 cases and radical therapy 50 Cases.The primary manner was wide excision of tumor and dissection of axillary lymph node.Adjuvant radiotherapy,chemotherapy and incretion treatment were given postoperatively.Results In 100 cases of breast cancer,the surviral of 83 cases(83.0%),17 patients(17.0%)died,30 cases(30.0%)of metastasis,local recurrence in 13 cases (13.0%);ER,PR-positive are 62 cases(62.0%),both wholly negative in 18 cases(18.0%),ER-positive only 12cases(12.0%),only 8 cases(8.0%)of PR positive;comparing two groups,survival and recurrent rate had no significant difference(X2=3.503,X2=4.284,P＞0.05),metastasis rate was significant different(X2=6.789,P＜0.05);satisfaction degree was 99.0% more than 12 months,and got ideal appearance was over 90%.Conclusion Breastconserving therapy can get long-term effect like Auchineol's.Breast-conserving therapy can gain good cosmetic resuits.
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Objective To study the value of BCSG1 on evaluating the curative effect of neoadjuvant chemotherapy(NC) for breast cancer.Methods The expression of BCSG1 in cancer tissue was assayed by immunohistochemistry and RT-PCR in 36 cases of breast cancer patients before and after receiving NC of CEF(cyclophosphamide,epirubicin and fluorouracil) regimen.The therapeutic response of NC was evaluated by morphological and pathological observation.The relationship between expression of BCSG1 and morphological response to NC was analyzed.Results Among the studied cases,the diameter of tumor significantly decreased(P
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ObjectiveTo investigate the feasibility and isolation efficiency of percutaneous selective isolated hepatic perfusion chemotherapy(PSIHP). MethodsSix pigs underwent the procedure of routine transhepatic arterial infusion(HAI) and 6 underwent PSIHP.5-FU was used in this study. The drug(5-FU) (concentration) of blood from hepatic and systemic veins of both groups was observed. Liver tissue was (investigated) for pathologic changes. ResultsThe peak level of 5-FU concentration in blood from right (hepatic) vein and systemic vein in HAI group was(4082.530415.213)mg/L and (1682.230216.834)mg/L respectively.In PSIHP group, the peak level(5-FU) was(5321.711517.318)mg/L and(510.83452.518)mg/L, respectively.There was a statistically significant difference between HAI group an PSIHP group(P