Metabolic Regulation of Cell Growth and Antimicrobial Metaboliteof the F0238 / 微生物学通报

Metabolic regulation of cell growth and antimicrobial metabolite of the F0238 was carried out in this study.The proper compositions of the culture medium and technological conditions for its fermentation were investigated.The results showed that the optimum conditions for the growth of the strain and its production of kojic acid were PDA medium with starch 2% as C source, peptone 0.2% as N source, and temperature 28℃, culture time 5 day (144 h), culture volume 80mL/500mL Erlenmeyer flask. Under above conditions, the dynamic curve of fermentation was obtained by an automatic mini-bioreactor of 10L and indicated a trend of decreasing pH, DO and residual sugar and increasing biomass and kojic acid production by F0238.