An orbital metastasis of prostate adenocarcinoma: A rare case report

A patient with known prostatic cancer presented with left supraorbital swelling with proptosis and restricted eye movements on left eye. Contrast enhanced computed tomography scan revealed dural and bone metastases with soft tissue component extending to the left orbit. Serum prostate specific antigen was markedly elevated at >100 ng/ml. Incision biopsy of the orbital tumor revealed only lymphocytic inflammatory cells within the fibrous stroma attributed mainly to the deeper location of the tumor or shallow locus of the biopsy. Incisional biopsy of the frontal bone revealed atypical looking cells in sheet cluster with nuclear enlargement, hyperchromatic in irregularity confirming the diagnosis of orbital metastasis of prostate carcinoma.Metastasis of prostate cancer to the orbit is rare. One should have a high index of suspicion of orbital metastasis when presented with an elderly patient with ocular symptoms and a history of prostate adenocarcinoma. A thorough clinical, radiological and histological evaluation is necessary to establish the diagnosis.

Ostrich eggshell as an onlay bone-graft substitute for orbital blow-out fractures

Methods: This is an experimental study of 12 rabbits implanted with ostrich eggshell (6 rabbits with 5mm- and 6 rabbits with 10mm-diameter grafts) subperiosteally in the right orbital floor. The right orbit was harvested en bloc 1, 2, and 3 months after onlay. Radiographic studies were done one day after implantation and prior to harvest. The specimens were submitted for gross and microscopic studies. Results: All animals showed normal wound healing. The grafts were stable and no foreign body reaction was observed 1, 2 and 3 months postimplantation. The size of the ostrich eggshell implants remained the same. There was no change in radiodensity at 3 months observation. Conclusion: The results of this study support the potential application of ostrich eggshell as bone substitute for orbital floor fractures.