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Objective To investigate the value of 11C-choline PET-CT imaging in the diagnosis of benign and malignant prostate lesions with high PSA.Methods A retrospective analysis of 11C-choline PET-CT imaging results of 43 prostate lesions cases with high PSA, including 21 cases of benign prostatic hyperplasia, 22 cases of prostate cancer, all cases were diagnosed by histopathology , data was accessed 5min after injection of 11C-choline , if suspected of metastasis, whole body 11C-choline PET-CT imaging was done.Standardized uptake value ( SUV) of prostatic hyperplasia and prostate cancer were calculated and analysed.Results More uniform uptake of the imaging agent showed in benign prostatic hyperplasia, uptake in the mild metabolic or nodular prostate symmetry slightly increased, the average SUV value 1.70 ± 1.09;focal asymmetry abnormal imaging agent uptake or diffuse abnormal uptake of the imaging agent of prostate cancer manifested in 11C-choline PET/CT imaging for prostate heterogeneity were increased, the average SUV values 3.29 ±1.55;The two groups had statistically significant.Four pelvic and retroperitone-al lymph node metastasis cases ,nine cases of bone metastasis and three cases of lung metastases was found in 11C-choline PET/CT imaging.Conclusions 11C-choline PET-CT imaging is not only a better differ-ential noninvasive imaging diagnosis method of benign and malignant prostate lesions with high PSA, but al-so has contribution to accurate preoperative staging of prostate cancer.
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BACKGROUND:Despite tissue repair with a kind of stem cels has achieved great outcomes, but the combination of two or more kinds of stem cels to construct tissue-engineered bone is stil rare. OBJECTIVE:To evaluate the efficacy of tissue-engineered bone constructed based on combining adipose-derived stem cels with bone marrow mesenchymal stem cels and alogenic bone in rabbit posterior intertransverse lumbar interbody fusion models. METHODS:Seventy-five New Zealand rabbits were randomly divided into five groups. L5,6 interbody fusion models were made in each group. Then, these five groups were respectively treated as folows (1) group A: bone marrow mesenchymal stem cels/alograft iliac bone with adipose-derived stem cels; (2) group B: bone marrow mesenchymal stem cels/alograft iliac bone with normal saline; (3) group C: alograft iliac bone with adipose-derived stem cels; (4) group D: alograft iliac bone with normal saline; group E: autologous iliac bone alone. Each group was detected by PET/CT to contrast the standard uptake value at 1, 3, 5 weeks postoperatively. RESULTS AND CONCLUSION: PET/CT images showed varying degrees of bone fusion and bone metabolism enhancement in the five groups. With time, the standard uptake value was increased in each group, and except the group D, the standard uptake value was higher in al the groups at 3, 5 weeks than at 1 week (P 0.05). The standard uptake value of the group A was better than that in the group B and group E (P < 0.05). Taken together, the combination of adipose-derived stem cels and bone marrow mesenchymal stem cels for rapid production of tissue-engineered bone has good osteogenesis and vascularization.