The frequency and severity of symptoms of major depression in Chinese patients with chronic, medically unexplained, painful physical symptoms who present to a general neurology clinic

This cross-sectional, non-interventional, observational study evaluated depression in patients in China who presented to a general neurologist with chronic, medically unexplained, painful physical symptoms. Of the 402 patients enrolled, 197 patients (49.0%) met the criteria for a current major depressive episode (MDE+ group), as assessed using module A of the Mini International Neuropsychiatric Interview, and 205 patients (51.0%) did not (MDE- group). The mean pain severity visual analogue scale (VAS) score was signifi cantly higher in the MDE+ group than the MDE- group (65.3 vs 55.6 mm; p<0.001). The mean depression severity score, as assessed using the 9-item Patient Health Questionnaire (PHQ-9), was 8.4 units (95% CI: 7.3 to 9.5) higher in the MDE+ group than the MDE- group (mean PHQ-9 total score: 14.8 vs 6.4). Anxiety and perceived health state were signifi cantly worse, on average, in the MDE+ group (mean Hospital Anxiety and Depression Scale anxiety subscale score 10.7 vs 5.9 units; mean EuroQoL-5 Dimensions VAS score 56.4 vs 67.7 mm; each p<0.001). Only 14.2% of patients had received treatment for depression during the past 3 months. These results suggest depression was common and may have been under-treated in this group of Chinese patients with chronic, medically unexplained painful physical symptoms.

Observation on the treatment of recurrent oral ulcer with the combination of vitamin B2 and Zhibaidihuangwan / 国际中医中药杂志

Objective To study the effect of combined vitamin therapy of B2 and Zhibai-Dihuang Wan on recurrent oral ulcer.Methods A total of 178 patients with recurrent oral ulcer were randomly recruited into a control group and a treatment group.The control group was treated with vitamin B2,0.2g/time,3 times/day;while the treatment group WaS treated with Zhibai-Dihuang Wan,9g/time,twice/day,on the basis of the control group.The therapeutic effects were observed in both groups after 14 days.Results The obvious effective rate in the treatment group was significantly higher than the control group(P=0.0083).while total effective rate did not show significant difierence between the two groups(P=0.0712).The relapse rate in the treatment group was significant lower than the control group.Conclusion It is effective to treat recurrent oral ulcer with the combination of vitamin B2 and Zhibai-Dihuang Wan.

Facial nerve injury in the surgical management of benign parotid tumor / 中国耳鼻咽喉头颈外科

OBJECTIVE To observe the incidence of facial nerve injury and its relationship to the types of operation. METHODS The clinical data of 116 patients who underwent parotid surgery from 1999 to 2006 were analyzed retrospectively. RESULTS The facial injury rate in total parotidectomy(66.7 %) was significantly higher than that in superfacial parotidectomy(39.2 %) and partial parotidectomy(12.5 %). The facial nerve injury rate in the mandibular branch(31.9 %) was higher than that in the buccal branch(9.2 %) and the zygomaticofacial branch(2.9 %). CONCLUSION The injury of facial nerve branches was correlated with the surgical managements. A proper surgical managements and operative extent would reduce the incidence of facial nerve injury and decrease the complications of the operation.

Mechanism of aprotinin in auxiliary treatment of cerebral hemorrhage / 中华神经科杂志

Objective To discuss the mechanism of aprotinin in auxiliary treatment of cerebral hemorrhage.Methods Totally 83 patients were divided into two groups: aprotinin treating group (42 cases) and control group (41 cases). The patients’ neurologic function was marked according to the European Standards of Grading For Cerebral Attacking. The volumes of edema were observed by CT in 10 days through 14 days after their attacks. The patients’ following prothrombin, activated partial thromboplastin time, and fibrinogen values were measured respectively before and after treatment.Results The therapeutic effects in aprotinin treating group(14.5?4.3, 19.0?5.2, 24.0?5.0, respectively) were significantly higher than those in control group(12.7?3.8, 16.8?4.8, 21.7?5.4, respectively).The producing of edema per day (0.212?0.064) in aprotinin treating group was significantly less than that in the control group(0.240?0.063). While the APTT after treatment was significantly longer ((1.2?1.8)s vs (0.4?1.8)s). Conclusions Aprotinin might inhibit the formation of cerebral edema and improve the neurologic function marks after attacks. It should be in treatment better to use aprotinin simultaneously than to use mannitol only. The mechanism properly shown is the preventive effects on bradykinin and thrombin.