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Chinese Journal of Biotechnology ; (12): 1659-1676, 2021.
Artículo en Chino | WPRIM | ID: wpr-878660

RESUMEN

Over the past 30 years, Yarrowia lipolytica, Kluyveromyces, Pichia, Candida, Hansenula and other non-conventional yeasts have attracted wide attention because of their desirable phenotypes, such as rapid growth, capability of utilizing multiple substrates, and stress tolerance. A variety of synthetic biology tools are being developed for exploitation of their unique phenotypes, making them potential cell factories for the production of recombinant proteins and renewable bio-based chemicals. This review summarizes the gene editing tools and the metabolic engineering strategies recently developed for non-conventional yeasts. Moreover, the challenges and future perspectives for developing non-conventional yeasts into efficient cell factories for the production of useful products through metabolic engineering are discussed.


Asunto(s)
Edición Génica , Ingeniería Metabólica , Pichia/genética , Biología Sintética , Yarrowia/genética , Levaduras
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