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OBJECTIVE:To effectively control the quality of intravenous infusion product of antitumor drugs in PIVAS,and to guarantee the safety of clinical drug use. METHODS:According to the operation flow of intravenous infusion product,the quality control of anti-tumor drugs was conducted in PIVAS of our hospital from three aspects,i.e. before,during and after admixture. The improvement effect was compared before and after the implementation. RESULTS:Pre-admixture management was carried out through special classification management and medical order check management for antitumor drug;intra-admixture management was carried out through the management of admixture environment,solvent selection,admixture method,order for adding drug, dosage;post-admixture management was carried out through standard examination of infusion product and the management of deliv-ery time and condition. 5 months later,the times of communication between PIVAS and clinical departments was decreased from 30 times to 10 times,and the incidence of infusion product was decreased from 0.68% to 0.18%. CONCLUSIONS:Standard man-agement has been conducted for operation procedure of anti-tumor drugs before,during and after admixture. The quality of intrave-nous infusion product of antitumor drugs can be effectively controlled to ensure the safety of clinical drug use.
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Objective To explore the relationship between single nucleotide polymorphisms (rs12953-717) of SMAD7 and susceptibility of non-small cell lung cancer (NSCLC) in Chinese Han population.Methods A single nucleotide polymorphisms (rs12953717) from SMAD7 was detected via Sequenom system in 528 NSCLC cases and 762 healthy controls.Data was statistically analyzed by unconditional Logistic regression method.Results rs12953717 had significant differences between non-small cell lung cancer patients and the controls.Compared with CC/TT (CC combined with TT) genotype,the adjusted odds ratio for the CT genotype was 4.107 (95％ CI:3.206 ～ 5.260,P =0.000 1).Smokers had a 2.004 odds ratio (95 ％ CI =1.583 ～ 2.537,P =0.000 1) of NSCLC compared with the controls.There was a 10.074-fold increased risk of NSCLC among the subjects with CT genotype and smokers.Conclusion The polymorphism of rs12953717 may have relation with risk of NSCLC.Heterozygote (CT) is a susceptibility genotype of NSCLC.Smoking is one of the risk factors of NSCLC.Smoking and CT genotype have synergistic effects on NSCLC susceptibility.