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Artículo en Inglés | IMSEAR | ID: sea-64603

RESUMEN

A study of the immunogenicity and safety of 20 micrograms recombinant DNA yeast derived hepatitis B vaccine was conducted in 153 Pakistani adults. All participants were in good physical condition, had negative hepatitis B serological markers (HBsAg, anti-HBs, anti-HBc) and normal ALT. Anti-HBs developed in 33%, 81% and 98% of subjects one month after the first, second and third dose respectively. Minor systemic and local side-effects were observed in 39% of individuals. We conclude that yeast derived hepatitis B vaccine is safe, effective and immunogenic in Pakistani adults.


Asunto(s)
Adolescente , Adulto , ADN Recombinante , Femenino , Hepatitis B/inmunología , Anticuerpos contra la Hepatitis B/análisis , Humanos , Masculino , Persona de Mediana Edad , Pakistán , Vacunación , Vacunas Sintéticas/inmunología , Vacunas contra Hepatitis Viral/inmunología , Levaduras/inmunología
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