RESUMEN
<p><b>OBJECTIVE</b>To determine the effects of Chinese herbal monomers such as baicalin, berberine, and matrine on the androgen receptor (AR) mRNA expression in SZ95 sebocytes in vitro and to explore the possible mechanism of using traditional Chinese medicines to treat acne.</p><p><b>METHODS</b>SZ95 sebocytes were cultured and then treated with berberine, baicalin, matrine, and 13-cis-retinoic acid for 24 hours. Reverse transcription polymerase chain reaction was applied to detect the changes of AR.</p><p><b>RESULT</b>AR mRNA was downregulated by 13-cis-retinoic acid of 1 x 10(-5) mol/L and 1 x 10(-6) mol/L, and by baicalin of 1 x 10(-4) mol/L (P < 0.05).</p><p><b>CONCLUSION</b>13-cis-retinoic acid and baicalin may exert antiandrogenitic action by inhibiting AR mRNA expression in human sebocytes.</p>
Asunto(s)
Humanos , Antagonistas de Andrógenos , Farmacología , Línea Celular , Regulación hacia Abajo , Medicamentos Herbarios Chinos , Farmacología , Flavonoides , Farmacología , ARN Mensajero , Receptores Androgénicos , Genética , Piel , Biología CelularRESUMEN
New studys on the sebaceous glands in recent years have facilitated the further understanding and treatment of acne vulgaris. This article summarizes the advancements in the relationship between sebaceous glands and acne, with focus on androgen metabolism in skin, abnormal lipids secretion, and immunology of sebaceous gland cells.